Browsing by Author "16386db5-a26d-4bad-a20d-cc62ad2a1733"
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In silico screening of tangible-potential inhibitor of methionine aminopeptidase 2 for the treatment of cancer
Methionine Aminopeptidases (MetAPs) are divalent-cofactor dependent enzymes that are responsible for cleaving the initiator Methionine from the newly synthesized polypeptides. These metalloproteases are classified into two distinct isoforms- MetAP1 and MetAP2. The MetAP2 isoform is upregulated in many cancerous cells. A selective inhibition of MetAP2 is an effective means of suppressing vascularization and limiting both the size and metastasis of solid tumors in a model organism. A selective and ...