Browsing by Author "İskit, Alper Bektaş"
New Human Monoamine Oxidase A Inhibitors with Potential Anti- Depressant Activity: Design, Synthesis, Biological Screening and Evaluation of Pharmacological Activity Authors:Evranos Aksöz, Begüm; Uçar, Gülberk; Taş, Sadık Taşkın; Aksöz, Erkan; Yelekçi, Kemal; Erikçi, Açelya; Sara, Yıldırım; İskit, Alper Bektaş
Publisher and Date:(Bentham Science, 2017)Aim and objective: Depression is a momentous disease that can greatly reduce the quality of life and cause death. In depression, neurotransmitter levels such as serotonine, dopamine and noradrenaline are impaired. Monoamine oxidases (MAO) are responsible for oxidative catalysis of these monoamine neurotransmitters. Because of this relation, MAO-A inhibitors show antidepressant activity by regulating neurotransmitter levels. This study was carried out to investigate the design, synthesis and activity ...