Browsing by Author "Dagistanli, Fatma Kaya"
Protective effects of a calcium channel blocker on apoptosis in thymus of neonatal STZ-diabetic rats Authors:Dagistanli, Fatma Kaya; Duman, Belgin Süsleyici; Ozturk M.
Publisher and Date:(Elsevier GMBH Urban & Fischer Verlag, 2005)Streptozotocin (STZ) is known to induce insulin-dependent diabetes in experimental animals. In STZ-induced diabetes atrophy of the thymus is caused by elevated intracellular calcium levels leading to apoptosis. Hyperglycemia is known to result in a decrease in numbers of T cells in the thymus and circulation. Intracellular calcium levels increase in diabetic animals after induction by STZ. Hyperglycemia inhibits Ca2+-ATPase and increases intracellular calcium levels. We have investigated apoptosis ...