Browsing by Author "Ersöz, Melike"
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Ginkgo biloba extract regulates differentially the cell death induced by hydrogen peroxide and simvastatin
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Publisher and Date:(Elsevier Science Bv, 2006)Several human diseases have been associated with the overproduction of reactive oxygen species (ROS) and subsequently various antioxidants emerged as potential therapeutic agents that scavenge ROS. As an oxidative stress model of human disease we used hydrogen peroxide (11202) to study effect of ROS on C6 glioma cells as a surrogate for astrocytes. H2O2 induced dose- and time-dependent apoptotic cell death which was preceded by growth arrest and transiently activated the signalling proteins ATF-2 ...
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Simvastatin induces proliferation inhibition and apoptosis in C6 glioma cells via c-jun N-terminal kinase
Authors:
Publisher and Date:(Elsevier Ireland Ltd., 2004)The lipid-lowering drugs statins induce apoptosis in a variety of tumor cells. Here we investigated the apoptotic effect of the lipophilic statin simvastatin in C6 glioma cells and the underlying effects on intracellular signal transduction. Simvastatin inhibited cell proliferation totally after 20 h of treatment as shown by the decrease in proliferating cell nuclear antigen expression in the nucleus. Subsequently simvastatin caused apoptotic cell death by shrinkage of cytoplasm and condensation ...
