Browsing by Author "Evranos-Aksoz, Begum"

Now showing items 1-3 of 3

Design and synthesis of novel 2-pyrazoline analogues and their hMAO inhibitory activities

Authors:Uçar, Gülberk; Evranos-Aksoz, Begum; Yabanoglu-Çiftçi, Samiye; Yelekçi, Kemal
Publisher and Date:(Wiley-Blackwell, 2015)
Synthesis and screening of hMAO inhibitory activities of some new 2-pyrazoline and hydrazone derivatives

Authors:Evranos-Aksoz, Begum; Yabanoglu-Ciftci, Samiye; Ucar, Gulberk; Yelekçi, Kemal; Ertan, Rahmiye
Publisher and Date:(Wiley-Blackwell, 2014)
Synthesis of some novel hydrazone and 2-pyrazoline derivatives: Monoamine oxidase inhibitory activities and docking studies

Authors:Evranos-Aksoz, Begum; Yabanoglu-Ciftci, Samiye; Ucar, Gulberk; Yelekçi, Kemal; Ertan, Rahmiye
Publisher and Date:(Pergamon-Elsevier Science Ltd, 2014)

A novel series of 2-pyrazoline and hydrazone derivatives were synthesized and investigated for their human monoamine oxidase (hMAO) inhibitory activity. All compounds inhibited the hMAO isoforms (MAO-A or MAO-B) competitively and reversibly. With the exception of 5i which was a selective MAO-B inhibitor all derivatives inhibited hMAO-A potently and selectively. According to the experimental K-i values compounds 6e and 6h exhibited the highest inhibitory activity towards the hMAO-A whereas compound ...