Browsing by Author "Isik, Samil"
Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors Authors:Gokhan-Kelekçi, Nesrin; Simsek, O. Ozgun; Ercan, Ayse; Yelekçi, Kemal; Sahin, Z. Sibel; Isik, Samil; Ucar, Gulberk; Bilgin, Abdullah Altan
Publisher and Date:(Pergamon-Elsevier Science Ltd, 2009)A novel series of 2-thiocarbamoyl-234567-hexahydro-1H-indazole and 2-substituted thiocarbamoyl-33a 4567-hexahydro-2H-indazoles derivatives were synthesized and investigated for the ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO). The target molecules were identified on the basis of satisfactory analytical and spectra data (IR H-1 NMR C-13 NMR D-2 NMR DEPT EI-MASS techniques and elemental analysis). Synthesized compounds showed high activity against both the MAO-A ...