Browsing by Author "Koyutürk, Meral"
Now showing items 1-18 of 18
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Effect of glurenorm on immunohistochemical changes in pancreatic β cells of rats in experimental diabetes
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Publisher and Date:(2005)Immunohistochemical localization of islets of Langerhans of streptozotocin (65 mg/kg ip) induced diabetic + glurenorm (10 mg/kg po) treated female albino rats revealed increase in number of β cells and insulin immunoreactivity of β cells. The results suggest that glurenorm can cause the stimulation of β cells of endocrine pancreas in diabetic rats.
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Effects of leucocytospermia on semen parameters and outcomes of intracytoplasmic sperm injection
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Publisher and Date:(Wiley, 2005)Leucocytes are present throughout the male reproductive tract but the clinical significance of leucocytic infiltration in the human ejaculate is controversial. The World Health Organization (WHO) defines leucocytospermia as the presence of peroxidase-positive leucocytes in concentrations of >= 1 x 10(6)/mL of semen. The goals of this study were to clarify the relationship between leucocytospermia and semen parameters including sperm concentration progressive and total motility before and after ...
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Effects of vanadyl sulfate on liver of streptozotocin-induced diabetic rats
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Publisher and Date:(Humana Press Inc., 2005)The aim of this study was to investigate the microscopic and biochemical effects of vanadyl sulfate on liver tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. Degenerative changes were observed in diabetic animals by light and transmission electron microscopes. Although there were individual differences in diabetic animals to which vanadium was given some reduction of degenerative changes were detected. After 60 d of ...
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Evaluation of the proliferating activities of normal and carcinomatous prostatic tissues with Ki-67
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Publisher and Date:(Haliç Üniv. Fen Edebiyat Fak., 2005)In this study proliferation activities of normal prostate tissue, benign prostate hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostate cancer samples were evaluated immunohistochemically by using the monoclonal anti-Ki-67 antibody. Ki-67 is a nuclear non-histone protein expressed throughout the cell cycle. The proliferation rate was found to be 0.3-0.8 % in normal prostate glandular epithelium, 0.5-2.2 % in BPH, 1.6-3.7 % in high grade PIN and 5-30 % in prostate cancer ...
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Ginkgo biloba extract regulates differentially the cell death induced by hydrogen peroxide and simvastatin
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Publisher and Date:(Elsevier Science Bv, 2006)Several human diseases have been associated with the overproduction of reactive oxygen species (ROS) and subsequently various antioxidants emerged as potential therapeutic agents that scavenge ROS. As an oxidative stress model of human disease we used hydrogen peroxide (11202) to study effect of ROS on C6 glioma cells as a surrogate for astrocytes. H2O2 induced dose- and time-dependent apoptotic cell death which was preceded by growth arrest and transiently activated the signalling proteins ATF-2 ...
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Hydrogen peroxide induces apoptosis of glioma cells via JNK activation
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Publisher and Date:(Histochemical Soc Inc, 2004)
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Influence of combined antioxidants against cadmium induced testicular damage
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Publisher and Date:(Elsevier Science Bv, 2006)Acute effects ofcadmium (Cd) and combined antioxidants were evaluated in Sprague-Dawley rat testes. The rats were subdivided into four groups. Cadmium chloride (2 mg/kg day) injected intraperitoneally during 8 days. Vitamin C (250 mg/kg day) vitamin E (250 rng/kgday) and sodium selenate (0.25 mg/kg day) were pretreated by gavage in both ofcontrol and cadmium injected rats. Testis lipid peroxidation and glutathione levels were determined by spectrophotometrically. In Cd treated rats lipid peroxidation ...
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Lökositosperminin semen ve intrasitoplazmik sperm enjesksiyonu parametreleri üzerine etkileri
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Publisher and Date:(Kadir Has University, 2004)İnfertilite, korunmasız olarak cinsel ilişkiye girilmesine rağmen, bir yılı aşan süreyle çiftlerin çocuk sahibi olamamasıdır. İnfertilite nedeniyle başvuran çiftlere yapılan araştırmalar sonunda, gerekirse yardımla üreme tekniklerinden yararlanılır. Bu yöntemlerden biri olan İntrasitoplazmik Sperm Enjeksiyonu (ICSI), ciddi erkek infertilitesi nedeniyle çocuk sahibi olamayan çiftler için sıkça başvurulan bir yöntemdir ve yumurtaların in vitro koşullarda spermatozoon hücreleri ile biraraya getirilip ...
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Preeklamptik ve normal plasentada endotelyal nitrik oksit sentetaz immünreaktivitesinin incelenmesi
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Publisher and Date:(2005)Bu çalışmada amaç, uteroplasental değişikliklerle ilişkili olduğu düşünülen endotelyal nitrik oksit sentetaz düzeylerinin (eNOS) preeklamptik ve kontrol gebelere ait fetal ve maternal yüz plasentalarında immünohistokimyasal olarak incelenmesidir. Çalışmada, 10 preeklamptik ve 5 normal kontrol grubu gebeye ait plasenta örnekleri ve kan değerleri incelendi. Son trimestir gebeliklerde proteinüri varlığı ve kan basıncı (>140/90 mm/Hg) değerlerine göre preeklampsi ve kontrol grupları belirlendi. ...
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Preeklamptik ve normal plasentada endotelyal nitrik oksit sentetaz immunreaktivitesinin incelenmesi
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Publisher and Date:(Kadir Has University, 2004)Çalışmada, 10 preeklamptik ve 5 normal kontrol grubu gebeye ait plasenta örnekleri ve kan değerleri incelendi. Son trimestir vakalarından proteinüri ve yüksek kan basıncı (> 140/90 mm/Hg) değerlerine göre preeklampsi ve kontrol grupları belirlendi. Preeklamptik ve normal plasenta doku örneklerinin maternal ve fetal yüzlerine ait toplam 30 parafin blok hazırlandı. Alınan kesitlerde endotelyal nitrik oksit sentetaz (eNOS) aktivasyonu streptavidin-biotin immünohistokimyasal yöntemi uygulanarak ...
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Protective effects of ascorbic acid DL-alpha-tocopherol acetate and sodium selenate on ethanol-induced gastric mucosal injury of rats
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Publisher and Date:(Humana Press Inc., 2004)In this study the effect of ascorbic acid (vitamin C) DL-alpha-tocopherol acetate (vitamin E) and sodium selenate (selenium) on ethanol-induced gastric mucosal injury in rats was investigated morphologically and biochemically. The gastric mucosal injury was produced by administration of 1 mL of absolute ethanol to each rat. Animals received vitamin C (250 mg/kg) vitamin E (250 mg/kg) and selenium (0.5 mg/kg) for 3 d 1 h prior to the administration of absolute ethanol. In gastric mucosa of rats ...
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Simvastatin induces proliferation inhibition and apoptosis in C6 glioma cells via c-jun N-terminal kinase
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Publisher and Date:(Elsevier Ireland Ltd., 2004)The lipid-lowering drugs statins induce apoptosis in a variety of tumor cells. Here we investigated the apoptotic effect of the lipophilic statin simvastatin in C6 glioma cells and the underlying effects on intracellular signal transduction. Simvastatin inhibited cell proliferation totally after 20 h of treatment as shown by the decrease in proliferating cell nuclear antigen expression in the nucleus. Subsequently simvastatin caused apoptotic cell death by shrinkage of cytoplasm and condensation ...
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Spermatozoon ve reaktif oksijen türevleri
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Publisher and Date:(2005)Reaktif oksijen türevleri (ROT), biyokimyasal olaylar zincirinde oksijenin organik maddelerle etkileşimi sonucu ortaya çıkan reaktif ara ürünlerdir. ROT’nin fizyolojik mekanizmalar›n düzenlenmesinde rol aldıkları bilinmektedir. Ancak hücrede, antioksidan kapasiteyi aşan miktarlardaki ROT üretimi, lipit, protein ve DNA hasar›na yol açmaktadır. Oksidatif stres olarak tanımlanan bu tablonun birçok hastalığın patojenezinde rol oynadığı bilinmektedir. ROT’nin spermatozoon üzerine etkilerinin ...
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Sıçan tiroid bezinde kadmiyum hasarına karşı C vitamini, E vitamini ve selenyumun kombine kullanımının etkileri
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Publisher and Date:(2004)Çalışmanın amacı sıçan tiroid bezinde kadmiyumun sebep olduğu hasara karşı C vitamini, E vitamini ve selenyumun koruyucu bir etkisinin olup olmadığını incelemek ve metallotionein ekspresyonunu tespit etmekti. Grup I: Dokunulmamış sıçanlardan; Grup II: 8 gün oral olarak sadece C vitamini (250 mg/kg/gün), E vitamini (250 mg/kg/gün) ve sodyum selenat (0.25 mg/kg/gün) verilen sıçanlardan; Grup III: İntraperitoneal olarak CdCl2 (2 mg/kg/gün) verilen sıçanlardan; Grup IV: Kadmiyum verilmesinden 1 saat ...
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The effects of vitamin C vitamin E and selenium against cadmium toxicity on liver of rats
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Publisher and Date:(Histochemical Soc Inc, 2004)
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The protective effect of vitamin C vitamin E and selenium combination therapy on ethanol-induced duodenal mucosal injury
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Publisher and Date:(Arnold Hodder Headline Plc., 2004)In this study the effect of a combination of vitamin C vitamin E and selenium on ethanol-induced duodenal mucosal damage in rats was investigated morphologically and biochemically. The duodenal mucosal injury was produced by oral administration of 1 mL of absolute ethanol to each rat. Animals received vitamin C ( 250 mg/ kg) vitamin E ( 250 mg/kg) and selenium (0.5 mg/kg) for 3 days and absolute ethanol 1 hour after last antioxidant administration and were sacrificed 1 hour after absolute ethanol. ...
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Thymidine labeling index and Ki-67 staining in breast cancer and their relationship to clinical and pathological variables
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Publisher and Date:(2004)
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Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis
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Publisher and Date:(2005)Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral to metastasis (e.g., proliferation, motility, secretion, and invasion), although their contribution to cancer progression has largely been ignored. The purpose of this study was to investigate voltage-gated Na + channel (VGSC) expression and its possible role in human breast cancer. Experimental Design: Functional VGSC expression was investigated in human breast cancer cell lines by patch clamp recording. ...
