Browsing by Author "Kulan, Handan"
Now showing items 1-3 of 3
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Importance of Regional Differences in Brain Throughout Aging for Down Syndrome
Authors:
Publisher and Date:(Association for Computing Machinery, 2018)Down syndrome (DS) which affects approximately one in 700 live births is caused by an extra copy of the long arm of human chromosome 21 (HSA21). Statistical analysis has been done for understanding the protein expression profiles based on age and sex differences in DS. In addition there are ongoing research efforts for comprehending expression patterns based on different brain regions. However little is known about the mechanisms of expression differences in brain regions throughout aging. Insights ...
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In silico identification of critical proteins associated with learning process and immune system for Down syndrome
Authors:
Publisher and Date:(Public Library Science, 2019)Understanding expression levels of proteins and their interactions is a key factor to diagnose and explain the Down syndrome which can be considered as the most prevalent reason of intellectual disability in human beings. In the previous studies the expression levels of 77 proteins obtained from normal genotype control mice and from trisomic Ts65Dn mice have been analyzed after training in contextual fear conditioning with and without injection of the memantine drug using statistical methods and ...
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Using machine learning classifiers to identify the critical proteins in Down syndrome
Authors:
Publisher and Date:(Association for Computing Machinery, 2018)Pharmacotherapies of intellectual disability (ID) are largely unknown as the abnormalities at the complex molecular level which causes ID are difficult to understand. Down syndrome (DS) which is the prevalent cause of ID and caused by an extra copy of the human chromosome21 (Hsa21) has been investigated on protein levels by using the Ts65Dn mouse model of DS which are orthologs of %50 of Hsa21 classical protein coding genes. Recent works have applied the classification methods to understand critical ...
