Browsing by Author "Yılmaz, Özgür"
Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (Type II) Authors:Yılmaz, Özgür; Bayer, Burak; Bekçi, Hatice; Uba, Abdullahi, I; Cumaoğlu, Ahmet; Yelekçi, Kemal; Küçükgüzel, S. Guniz
Publisher and Date:(Bentham Science PUBL LTD, 2020)Background: Prostate cancer is still one of the serious causes of mortality and morbidity in men. Despite recent advances in anticancer therapy, there is a still need of novel agents with more efficacy and specificity in the treatment of prostate cancer. Because of its function on angiogenesis and overexpression in the prostate cancer, methionine aminopeptidase-2 (MetAP-2) has been a potential target for novel drug design recently. Objective: A novel series of Flurbiprofen derivatives ...
Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives Authors:Uba, Abdullahi İbrahim; Karasulu, Hatice Yeşim; Karasulu, Ercüment; Birgül, Kaan; Yıldırım, Yeliz; Bekçi, Hatice; Cumaoğlu, Ahmet; Yılmaz, Özgür; Kabasakal, Levent; Küçükgüzel, Şükriye Güniz; Yelekçi, Kemal
Publisher and Date:(Elsevier Masson s.r.l., 2020)In this study, (S)-naproxen thiosemicarbazides (3a-d), 1,2,4-triazoles (4a-c), triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d, 4a and 5a-p) were confirmed by FT-IR, 1H NMR,13C NMR, HR-Mass spectra and elemental analysis. These compounds are designed to inhibit methionine amino peptidase-2 (MetAP2) enzyme in prostate cancer. These compounds (3d, 5a-p) evaluated against androgen-independent prostate adenocarcinoma (PC-3, DU-145) and androgen-dependent ...