Browsing by Author "Yanardağ, Refiye"
Effect of glurenorm on immunohistochemical changes in pancreatic β cells of rats in experimental diabetes Authors:Koyutürk, Meral; Özsoy-Saçan, Özlem; Bolkent, Şehnaz; Yanardağ, Refiye
Publisher and Date:(2005)Immunohistochemical localization of islets of Langerhans of streptozotocin (65 mg/kg ip) induced diabetic + glurenorm (10 mg/kg po) treated female albino rats revealed increase in number of β cells and insulin immunoreactivity of β cells. The results suggest that glurenorm can cause the stimulation of β cells of endocrine pancreas in diabetic rats.
Authors:Koyutürk, Meral; Tunali, Sevim; Bolkent, Şehnaz; Yanardağ, Refiye
Publisher and Date:(Humana Press Inc., 2005)The aim of this study was to investigate the microscopic and biochemical effects of vanadyl sulfate on liver tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. Degenerative changes were observed in diabetic animals by light and transmission electron microscopes. Although there were individual differences in diabetic animals to which vanadium was given some reduction of degenerative changes were detected. After 60 d of ...
Authors:Koyutürk, Meral; Yanardağ, Refiye; Bolkent, Şehnaz; Tunalı, Sevim
Publisher and Date:(Elsevier Science Bv, 2006)Acute effects ofcadmium (Cd) and combined antioxidants were evaluated in Sprague-Dawley rat testes. The rats were subdivided into four groups. Cadmium chloride (2 mg/kg day) injected intraperitoneally during 8 days. Vitamin C (250 mg/kg day) vitamin E (250 rng/kgday) and sodium selenate (0.25 mg/kg day) were pretreated by gavage in both ofcontrol and cadmium injected rats. Testis lipid peroxidation and glutathione levels were determined by spectrophotometrically. In Cd treated rats lipid peroxidation ...
Sıçan tiroid bezinde kadmiyum hasarına karşı C vitamini, E vitamini ve selenyumun kombine kullanımının etkileri Authors:Bulan, Karabulut Ömür; Koyutürk, Meral; Bolkent, Şehnaz; Yanardağ, Refiye; Oğuz, Tabakoğlu Ayşe
Publisher and Date:(2004)Çalışmanın amacı sıçan tiroid bezinde kadmiyumun sebep olduğu hasara karşı C vitamini, E vitamini ve selenyumun koruyucu bir etkisinin olup olmadığını incelemek ve metallotionein ekspresyonunu tespit etmekti. Grup I: Dokunulmamış sıçanlardan; Grup II: 8 gün oral olarak sadece C vitamini (250 mg/kg/gün), E vitamini (250 mg/kg/gün) ve sodyum selenat (0.25 mg/kg/gün) verilen sıçanlardan; Grup III: İntraperitoneal olarak CdCl2 (2 mg/kg/gün) verilen sıçanlardan; Grup IV: Kadmiyum verilmesinden 1 saat ...
The protective effect of vitamin C vitamin E and selenium combination therapy on ethanol-induced duodenal mucosal injury Authors:Koyutürk, Meral; Bolkent, Şehnaz; Özdil, S; Arbak, Serap; Yanardağ, Refiye
Publisher and Date:(Arnold Hodder Headline Plc., 2004)In this study the effect of a combination of vitamin C vitamin E and selenium on ethanol-induced duodenal mucosal damage in rats was investigated morphologically and biochemically. The duodenal mucosal injury was produced by oral administration of 1 mL of absolute ethanol to each rat. Animals received vitamin C ( 250 mg/ kg) vitamin E ( 250 mg/kg) and selenium (0.5 mg/kg) for 3 days and absolute ethanol 1 hour after last antioxidant administration and were sacrificed 1 hour after absolute ethanol. ...