Now showing items 1-5 of 5

  • Homology modeling and normal mode analysis of human NR1-NR2A NMDA type receptors 

    Authors:Demir, Ayhan S.
    Publisher and Date:(Kadir Has University, 2017)
    N-Methyl-D-Aspartate (NMDA) receptors are ionotropic glutamate receptors located in the membrane of the nerve cells. The normal receptor activity has a vital importance in consciousness and normal brain functions. Neuronal death occurs as a result of overstimulation of NMDA-type glutamate receptors and leads to diseases such as stroke epilepsy Alzheimer's and Parkinson's. There are two recently available x-ray structures one from Xenopus laevis and the other one from Rattus norvegicus. First the ...

  • In silico design and modeling of peptidomimetic drug candidates for methionine aminopeptidase 2 enzyme for prevention of cancer 

    Authors:Şentürk, Naz Şafak
    Publisher and Date:(Kadir Has University, 2019)
    Several disorders come together to form cancer. Cancer cells divide without a control. The cell proliferation in cancer is abnormal. More than 200 types of cancer have been diagnosed over the years. There are various factors that can cause cancer. These factors are heredity, diet, hormones, smoking, alcohol, viruses, bacteria, radiation and some chemicals. 17 million new cancer cases and 9.5 million cancer deaths were observed in 2018. Methionine Aminopeptidase 2 (MetAP 2) is a cobalt-containing ...

  • Novel inhibitor design for histone demethylase 1 (lsd1) enzyme using molecular modeling 

    Authors:Alshafeay, Marwah
    Publisher and Date:(Kadir Has University, 2019)
    Cancer is the most lethal disease among all known diseases and comprises the largest segment of death causes. Although many factors have direct involvement in cancer triggering, still the complete understanding behind the main cause of cancer is unrevealed. Recent studies have shown that the epigenetic process plays an ultimate role in cancer initiation. DNA methylation and histone modification are considered the most common systems that might cause epigenetic changes. Histone lysine specific ...

  • Oscillations and chaos in gene network models 

    Authors:Arıkan, Büşra
    Publisher and Date:(Kadir Has University, 2017)
    Oscillations and chaos have always been interesting topics in the theory of dynamical systems. In systems biology, oscillations emerging from gene networks are known to be widespread as in circadian oscillations, various metabolic cycles and the cell cycle to name a few. According to the dynamical systems theory, chaotic behavior can also be produced in strongly-coupled gene regulatory networks(GRNs) with dimensions equal to or exceeding three. Although there is a large number of studies focusing ...

  • Targeting cancer epigenetic modifiers: The design of isoform-selective histone deacetylase inhibitors 

    Authors:Uba, Abdullahi İbrahim
    Publisher and Date:(Kadir Has University, 2018)
    Epigenetic alterations are believed to be the common hallmark of human cancers. Histone deacetylase (HDAC) inhibitors have proven to be effective in cancer cases where HDACs are up-regulated. However lack of selectivity of many of the HDAC inhibitors in clinical use and those at various stages of preclinical and clinical trials causes toxicity to the normal cells. it is believed that the continuous identification of isoform-selective HDAC inhibitors can eliminate this adverse effect — a task that ...