Browsing by Publisher "Elsevier Sci Ltd"
Now showing items 1-2 of 2
Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6 Authors:
Publisher and Date:(Elsevier Sci Ltd, 2018)Histone deacetylase (HDAC) 6 plays a role in oncogenic transformation and cancer metastasis via tubulin deacetylation, making it a critical target for anticancer drug design. However, lack of selectivity shown by many of the current HDAC6 inhibitors in clinical use and trials prompts the continuous search for selective inhibitors. Here, 10 pharmacophore hypotheses were developed based on the 3D common features of training set of 20 HDAC inhibitors in clinical use and trials. The hypotheses were ...
Publisher and Date:(Elsevier Sci Ltd, 2018)The transition to a low-carbon energy economy will remain a cornerstone of national energy policies of countries committed to the climate change accord for decades to come. We think that transmission investment is one key policy instrument amongst other to help with this transition. We propose an enhanced role for investing in transmission capacity for inter-regional trade to allow effective fuel switching among countries through a physically connected market. We develop a conceptual framework of ...