Browsing by Publisher "Public Library Science"
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A Wrench in the Works of Human Acetylcholinesterase: Soman Induced Conformational Changes Revealed by Molecular Dynamics Simulations Authors:
Publisher and Date:(Public Library Science, 2015)Irreversible inactivation of human acetylcholinesterase (hAChE) by organophosphorous pesticides (OPs) and chemical weapon agents (CWA) has severe morbidity and mortality consequences. We present data from quantum mechanics/molecular mechanics (QM/MM) and 80 classical molecular dynamics (MD) simulations of the apo and soman-adducted forms of hAChE to investigate the effects on the dynamics and protein structure when the catalytic Serine 203 is phosphonylated. We find that the soman phosphonylation ...
Publisher and Date:(Public Library Science, 2018)The present study investigates the relationship between the attachment dimensions (anxious vs. avoidance) and the cognitive performance of individuals specifically whether the attachment dimensions would predict the working memory (WM) performance. In the n-back task reflecting the WM capacity both attachment related and non-attachment related words were used. Participants were randomly assigned into two groups that received either the secure or the neutral subliminal priming. In the secure priming ...
In silico identification of critical proteins associated with learning process and immune system for Down syndrome Authors:
Publisher and Date:(Public Library Science, 2019)Understanding expression levels of proteins and their interactions is a key factor to diagnose and explain the Down syndrome which can be considered as the most prevalent reason of intellectual disability in human beings. In the previous studies the expression levels of 77 proteins obtained from normal genotype control mice and from trisomic Ts65Dn mice have been analyzed after training in contextual fear conditioning with and without injection of the memantine drug using statistical methods and ...