Browsing by Publisher "Tübitak"
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Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies Authors:
Publisher and Date:(Tübitak, 2014)New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.
The Dikili-Çandarlı volcanics, western Turkey: Magmatic interactions as recorded by petrographic and geochemical features Authors:
Publisher and Date:(Tübitak, 2007)Located in the northwestern part of the Aegean region, Dikili-Çandarl› volcanic suite contains products representative for the western Anatolian Miocene volcanism. They can be divided into two main groups: the Dikili and the Çandarl› groups. The Dikili group is Early–Middle Miocene in age and consists mainly of pyroclastic rocks, andesitic-dacitic lavas, lava breccia, lahar flows and associated sedimentary rocks. The lavas contain disequilibrium phenocrysts assemblages. The Çandarl› group ...
Exploration of the binding pocket of histone deacetylases: the design of potent and isoform-selective inhibitors Authors:
Publisher and Date:(Tübitak, 2017)Histone deacetylases (HDACs) are enzymes that act on histone proteins to remove the acetyl group and thereby regulate the chromatin state. HDACs act not only on histone protein but also nonhistone proteins that are key players in cellular processes such as the cell cycle, signal transduction, apoptosis, and more. “Classical” HDACs have been shown to be promising targets for anticancer drug design and development. However, the selectivity of HDAC inhibitors for HDAC isoforms remains the motivation ...