Browsing by Subject "BP1-BP2 deletion"
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New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes Authors:
Publisher and Date:(Company of Biologists Ltd, 2017)Cytoplasmic FMRP interacting protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID) autism schizophrenia and epilepsy. It is a member of a family of proteins that is highly conserved during evolution sharing high homology with its Drosophila homolog dCYFIP. CYFIP1 interacts with the Fragile X mental retardation protein (FMRP encoded by the FMR1 gene) whose absence causes Fragile X syndrome and with the translation initiation factor eIF4E. It is a member of theWAVE regulatory complex ...