Browsing by Subject "Drug design"
Now showing items 1-2 of 2
Publisher and Date:(Kadir Has University, 2012)in drug development studies a large number of new drug candidates (leads)have to be synthesized and optimized by changing several moieties of the leads in order to increase efficacies and decrease toxicities. Each synthesis of these new drug candidates include multi-steps procedures. -- Abstract'dan.
In silico screening of multi target drug for alzheimer'sdisease and parkinson's disease using pharmacophore-baseddrug discovery approach Authors:
Publisher and Date:(Kadir Has University, 2019)Research on neurodegenerative diseases (NDD), commonly known as Alzheimer's and Parkinson's disease are the most important concern in this aging society. Among the other causes the main suspected reasons are the production and precipitation of the beta amyloid plaques as well as the decrease of acetyl and butyryl choline neurotransmitter in the brain. This eventually results in dementia in older people. APOE (apolipoprotein) alleles (genes) are very important for the genetic determination of ...