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  • In silico identification of novel and selective monoamine oxidase B inhibitors 

    Authors:Yelekçi, Kemal; Büyüktürk, Bora; Kayrak, Nurdan
    Publisher and Date:(SPRINGER WIEN, 2013)
    Monoamine oxidases (MAO) A and B are flavin adenine dinucleotides containing enzymes bound to the mitochondrial outer membranes of the cells of the brain liver intestine and placenta as well as platelets. Recently selective MAO-B inhibitors have received increasing attention due to their neuroprotective properties and the multiple roles they can play in the therapy of neurodegenerative disorders. This study was based on 10 scaffolds that were selected from more than a million lead compounds in the ...