Browsing by Subject "Prostate cancer"
Now showing items 1-4 of 4
Evaluation of the proliferating activities of normal and carcinomatous prostatic tissues with Ki-67 Authors:
Publisher and Date:(Haliç Üniv. Fen Edebiyat Fak., 2005)In this study proliferation activities of normal prostate tissue, benign prostate hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostate cancer samples were evaluated immunohistochemically by using the monoclonal anti-Ki-67 antibody. Ki-67 is a nuclear non-histone protein expressed throughout the cell cycle. The proliferation rate was found to be 0.3-0.8 % in normal prostate glandular epithelium, 0.5-2.2 % in BPH, 1.6-3.7 % in high grade PIN and 5-30 % in prostate cancer ...
Synthesis molecular modeling in vivo study and anticancer activity of 124-triazole containing hydrazide-hydrazones derived from (S)-naproxen Authors:
Publisher and Date:(Wiley-VCH Verlag GmbH, 2019)A new series of 124-triazole containing hydrazide-hydrazones derived from (S)-naproxen (7a-m) was synthesized in this study. The structures of these compounds were characterized by spectral (Fourier-transform infrared spectroscopy H-1-nuclear magnetic resonance (NMR) C-13-NMR and high-resolution electron ionization mass spectrometry) methods. Furthermore molecular modeling of these compounds was studied on human methionine aminopeptidase-2. All synthesized compounds were screened for anticancer ...
Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (Type II) Authors:
Publisher and Date:(Bentham Science PUBL LTD, 2020)Background: Prostate cancer is still one of the serious causes of mortality and morbidity in men. Despite recent advances in anticancer therapy, there is a still need of novel agents with more efficacy and specificity in the treatment of prostate cancer. Because of its function on angiogenesis and overexpression in the prostate cancer, methionine aminopeptidase-2 (MetAP-2) has been a potential target for novel drug design recently. Objective: A novel series of Flurbiprofen derivatives ...
Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives Authors:
Publisher and Date:(Elsevier Masson s.r.l., 2020)In this study, (S)-naproxen thiosemicarbazides (3a-d), 1,2,4-triazoles (4a-c), triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d, 4a and 5a-p) were confirmed by FT-IR, 1H NMR,13C NMR, HR-Mass spectra and elemental analysis. These compounds are designed to inhibit methionine amino peptidase-2 (MetAP2) enzyme in prostate cancer. These compounds (3d, 5a-p) evaluated against androgen-independent prostate adenocarcinoma (PC-3, DU-145) and androgen-dependent ...