Browsing by Subject "X-ray crystallographic model"
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Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors Authors:
Publisher and Date:(Pergamon-Elsevier Science Ltd, 2009)A novel series of 2-thiocarbamoyl-234567-hexahydro-1H-indazole and 2-substituted thiocarbamoyl-33a 4567-hexahydro-2H-indazoles derivatives were synthesized and investigated for the ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO). The target molecules were identified on the basis of satisfactory analytical and spectra data (IR H-1 NMR C-13 NMR D-2 NMR DEPT EI-MASS techniques and elemental analysis). Synthesized compounds showed high activity against both the MAO-A ...