Now showing items 1-1 of 1

  • In silico design of novel and highly selective cyclooxygenase-2 inhibitors 

    Authors:Mehmetoğlu, Tuğba
    Publisher and Date:(Kadir Has University, 2014)
    For many years, prevention of inflammation is achieved by inhibition of both cyclooxygenase (COX) enzymes; the eventual outcome is gastrointestinal toxicity. Selective inhibitor design for COX-2 initialized just after discovery of two distinct types of COX enzymes. Both isoforms of COX show great similarities at the active sites. It is still essential to find more potent, more selective and reversible COX-2 inhibitors. Crystallographic structures of COX-1 (pdb code: 1Q4G; Ovis aries COX-1 crystallized ...