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  • In silico design and modeling of coumarin derivatives as selective monoamine oxidase a inhibitors 

    Authors:Karaman, Dilara
    Publisher and Date:(Kadir Has University, 2014)
    Selective and reversible inhibition of Monoamine Oxidase (MAO) isoenzymes has an important place in treatment of various neurological disorders. Out of the two isoforms of Monoamine Oxidase enzymes inhibition of MAO-A have been giving positive results in treatment of depression and inhibition of MAO-B in cure of Parkinson’s disease. The difference in treatment is due to the fact that these two enzymes have different substrate specificities. in this study 125 different coumarin derivatives were ...