This experimental study was designed to examine whether hyperuricemia in hypothyroidism is associated with insulin resistance. For induction of hypothyroidism rabbits (n = 12) were administered methimazole orally (75 mg/100 g food) for 30 days. T-3 T-4 and TSH values measured in plasma prior to and at the end of the experimentation period revealed the establishment of hypothyroidism. In the euthyroid and hypothyroid states of rabbits crystalline porcine insulin was administered (0.1 unit/kg body ...