Browsing Araştırma Çıktıları / WOS by Author "Sahin, H. Bahar"
New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes Authors:Abekhoukh, Sabiha; Sahin, H. Bahar; Grossi, Mauro; Zongaro, Samantha; Maurin, Thomas; Madrigal, Irene; Kazue-Sugioka, Daniele; Raas-Rothschild, Annick; Doulazmi, Mohamed; Carrera, Pilar; Stachon, Andrea; Scherer, Steven; Do Nascimento, Maria Rita Drula; Trembleau, Alain; Arroyo, Ignacio; Szatmari, Peter; Smith, Isabel M.; Mila, Montserrat; Smith, Adam C.; Giangrande, Angela; Caille, Isabelle; Bardoni, Barbara
Publisher and Date:(Company of Biologists Ltd, 2017)Cytoplasmic FMRP interacting protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID) autism schizophrenia and epilepsy. It is a member of a family of proteins that is highly conserved during evolution sharing high homology with its Drosophila homolog dCYFIP. CYFIP1 interacts with the Fragile X mental retardation protein (FMRP encoded by the FMR1 gene) whose absence causes Fragile X syndrome and with the translation initiation factor eIF4E. It is a member of theWAVE regulatory complex ...
Authors:Sahin, H. Bahar; Karatas, Omer Faruk; Specchia, Valeria; Di Tommaso, Silvia D.; Diebold, Celine; Bozzetti, Maria Pia; Giangrande, Angela
Publisher and Date:(Taylor & Francis Inc, 2016)Aubergine is an RNA-binding protein of the Piwi clade functioning in germline in the piRNA pathway that silences transposons and repetitive sequences. Several mutations of this gene exist but they mostly result in truncated proteins or correspond to mutations that also affect neighboring genes. We have generated complete aubergine knock-out mutants that do not disrupt the neighboring genes. These novel mutants are characterized by PCR and sequencing. Their nature is confirmed by female sterility ...