Glikolitik yolaktaki en kritik enzimlerden biri olan fosfofruktokinaz (PFK), türe özgü ilaç tasarım çalışmalarında kullanılmak üzere hedeflenmiş ve bakteri, parazit ve insan olmak üzere üç türdeki allosterik bağlanma bölgeleri araştırılmıştır. Evrimsel süreçte allosterik bölgeler, proteinlerin aktif bölgesinden daha az korunmuş oldukları için, türe özgü ilaç ilaç tasarım çalışmaları için güçlü hedef bölgeler haline geldiler. Bu doğrultuda, çözücü haritalama, elastik ağ modeli, dizi ve yapı hizalama ...

İkinci Dunya Savasindan sonra dunya siyaseti yeniden sekillenmeye baslamistir. Dunyanin iki kutba ayrilmasiyla baslayan surec zaman icerisinde mutasyonlara ugramistir. Sovyetlerin yikilmasindan sonra her seyin cok farkli olacagi dusuncesi kismen dogru cikmistir. Bu senaryoda Amerika Birlesik Devletleri ve Sovyet Sosyalist Cumhuriyetler Birligi basroldeydi. Kimileri Sovyetlerin yikilmasindan sonra boyle bir statunun tekrar ortaya cikmasinin imkansiz oldugunu dusunmustur. Ne var ki her gecen gun ...

From the first cinematic screening to this day, the basic concern of the mainstream cinema had been its attraction from the audience. Cinema enlarged its frame, curved its screen, darkened its theater, used multiple projectors and screens, added sound and color, used surrounding system in sound, added third dimension by using additional glasses, in order to make the audience immersed in the narrative, and to create an impression of reality. In the digital era, cinema as many other art forms ...

This thesis examines the relationship between audience feedback and selfrepresentation on Facebook using Erving Goffman's dramaturgical model, focusing on the conceptions of audience and context on Facebook of Facebook-using students at Kadir Has University. I am exploring participants' perspectives in four main areas: Audience Feedback on Facebook user's posts and photos; examining user's response to audience feedback; investigating user's self-representation on Facebook; and finally examining ...

This study is done to explore and define the impact of human resource practices on job satisfaction of employees in ALKURAIMI bank in Yemen. In a world full of changes there is a crucial need to acquire better knowledge about the problems and things that affects employees since the employees are the most important asset for any organization. The core objective of this research is to find and explore the impact of human resource management practices in ALKURAIMI bank in Yemen. These practices include ...

Since the World War ii governments have thought economic sanctions as an option in order to influence the behavior of target countries. The question which economic sanctions can influence the behavior of a country without resulting into military actions exists. Most of previous studies investigated different ways in which and how economic sanctions can be effective through impose of pressure on the targeted country. in this study the importance of the problem and the impact of economic sanctions ...

Over the 1990s, most developing countries considered a series of market reforms, including the opening of their capital accounts. The role of Foreign Direct Investment (FDI) in the growth process has been recognized by policy makers. Capital Flows could affect domestic investment in several ways. Firstly, FDI contributes directly to new plant and equipment, the so-called ?greenfield? FDI. Secondly, due to linkages between firms, FDI may deliver spillover investment, beyond any direct increase in ...

Several frameworks tools and standards have been included in iT management systems in organizations such as COBiT CMMS. These days iT management is focusing particularly on the de facto standard iTiL for implementing iT service management. The information Technology infrastructure Library (iTiL) is a public framework that describes good practices in iT service management. it has been drawn from both the public and private sectors internationally. iTiL helps organizations to become aware of the ...

Data Mining usage in Health Sector increased much in this decade because of the need

Indoor positioning applications needs high accuracy and precision to overcome the existing obstacles and relatively small areas. There are several methods which could be used to locate an object or people in an indoor location. Specifically, Ultra-wide band (UWB) sensor technology is a promising technology in indoor environments because of its high accuracy, resistance of interference and better penetrating. This thesis is focused on improving the accuracy of UWB sensor based indoor positioning ...