Browsing by Title
Now showing items 1449-1468 of 3419
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‘I am here’: women workers’ experiences at the former Cibali Tekel Tobacco and Cigarette Factory in Istanbul
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Publisher and Date:(Routledge, 2017)This study presents oral history research which investigated the experiences of surviving women workers from the former Cibali Tekel Tobacco and Cigarette Factory in Istanbul Turkey. For most of its history the factory was home to thousands of workers many of who were women and at times outnumbered men two to one. While the site is now known for the university that it houses photographs and archival records from the early twentieth century reveal the centrality of women in the process and production ...
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I Hear you: Soundwalking in Tarlabaşı
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Publisher and Date:(Kadir Has University, 2013)Bu tez ses calismalari kapsaminda sehirlesmis alanlari odagina alir soundwalking yontemiyle ve sehrin kendi seslerini dinlemek marifetiyle Tarlabasi ornegi uzerinden sehirleri anlamlandirmanin yontemlerini kesfetmeye calisir. Ýlk bolum literatur taramasi ve bu alandaki boslugun tanimlanmasindan olusur. Ýkinci bolum soundwalking metodunu ve farkli kullanimlarini inceler. ucuncu bolumse metodun Tarlabasi’nda uygulamasinin sonuclarini sunar. Sonuc bolumundeyse metod ve sonuclar degerlendirilerek ...
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Identification of Alternative Allosteric Sites in Glycolytic Enzymes for Potential Use as Species-Specific Drug Targets
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Publisher and Date:(Frontiers Media, 2020)Three allosteric glycolytic enzymes, phosphofructokinase, glyceraldehyde-3 phosphate dehydrogenase and pyruvate kinase, associated with bacterial, parasitic and human species, were explored to identify potential allosteric sites that would be used as prime targets for species-specific drug design purposes using a newly developed approach which incorporates solvent mapping, elastic network modeling, sequence and structural alignments. The majority of binding sites detected by solvent mapping ...
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Identification of critical proteins associated with learning process for Down syndrome / Down sendromunda öğrenme sureci ile ilişkili kritik proteinlerin belirlenmesi
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Publisher and Date:(Kadir Has Üniversitesi, 2020)DS protein profilleri laboratuvarda biyokimyasal teknikler uygulayarak gözlemlenmektedir. Fakat, elde edilen protein listesi uzundur ve listedeki her protein DS ile alakalı değildir. Bu yüzden, DS analizi ve tedavisinde, protein ifade miktarları istatiksel metodlar ve makine öğrenmesi teknikleri uygulayarak analiz edilmektedir. Bu tezde, önceki çalışmalara kıyasla, farklı öndeğerlendirme adımları, özellik seçimi ve sınıflandırma teknikleri, farklı veri setleri için protein altkümeleri belirlenmesi ...
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Identification of distinct communication networks in human β2 adrenergic receptor via molecular dynamics simulation / Moleküler dinamik simülasyonu ile insan β2 adrenerjik reseptöründeki belirgin iletişim ağlarının tanımlanması
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Publisher and Date:(Kadir Has Üniversitesi, 2020)G-protein-bağlı reseptörler (GPCR), hücre dışı ligand bağlanma işlemini hücre içi tepkilere dönüştürerek çok çeşitli insan fizyolojik fonksiyonlarına aracılık eden ve yedi transmembran (TM) yapısından oluşan proteinlerdir. Karşılıklı sinyal aktarımı, ancak iki uzak bölge arasında allosterik iletişimle oluşur. Hem inaktif hem de aktif kristal yapıların mevcut olduğu bir arketipik GPCR olan insan β2-adrenerjik reseptörüne (β2AR) odaklandık. β2AR 'ın farklı konformasyonlarının yörüngelerini oluşturmak ...
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Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and molecular dynamics studies
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Publisher and Date:(Elsevier, 2020)Methionine Aminopeptidases MetAPs are divalent-cofactor dependent enzymes that are responsible for the cleavage of the initiator Methionine from the nascent polypeptides. MetAPs are classified into two isoforms: namely, MetAP1 and MetAP2. Several studies have revealed that MetAP2 is upregulated in various cancers, and its inhibition has shown to suppress abnormal or excessive blood vessel formation and tumor growth in model organisms. Clinical studies show that the natural product fumagillin, and ...
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Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: a combined approach of structure-based virtual screening ADMET prediction and molecular dynamics simulation assay
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Publisher and Date:(Taylor & Francis Inc, 2018)Histone deacetylases (HDACs) have gained increased attention as targets for anticancer drug design and development. HDAC inhibitors have proven to be effective for reversing the malignant phenotype in HDAC-dependent cancer cases. However lack of selectivity of the many HDAC inhibitors in clinical use and trials contributes to toxicities to healthy cells. It is believed that the continued identification of isoform-selective inhibitors will eliminate these undesirable adverse effects - a task that ...
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Identification of species-specific allosteric binding sites in phosphofructokinase for drug design studies / İlaç tasarım çalışmaları için fosfofruktokinaz enziminde türe özgü allosterik bağlanma bölgelerinin belirlenmesi
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Publisher and Date:(Kadir Has Üniversitesi, 2020)Glikolitik yolaktaki en kritik enzimlerden biri olan fosfofruktokinaz (PFK), türe özgü ilaç tasarım çalışmalarında kullanılmak üzere hedeflenmiş ve bakteri, parazit ve insan olmak üzere üç türdeki allosterik bağlanma bölgeleri araştırılmıştır. Evrimsel süreçte allosterik bölgeler, proteinlerin aktif bölgesinden daha az korunmuş oldukları için, türe özgü ilaç ilaç tasarım çalışmaları için güçlü hedef bölgeler haline geldiler. Bu doğrultuda, çözücü haritalama, elastik ağ modeli, dizi ve yapı hizalama ...
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Identifying City Differences in Perceived Group Discrimination among Second-generation Turks and Moroccans in Belgium
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Publisher and Date:(Routledge Journals Taylor & Francis Ltd, 2015)This study investigates the effects of city context on the levels and predictors of perceived group discrimination (GD) among Turkish and Moroccan second-generation immigrants in Belgium. Based on the Integration of the European Second-generation (TIES) data we address two main questions: (1) Are there significant differences in the levels of perceived GD between the two cities in Belgium (Antwerp and Brussels) within each immigrant group? (2) Who perceives more GD within each city? To answer these ...
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Identifying the working principles of human DNA methyltransferase 3A enzyme by computational methods / İnsan DNA metiltransferaz enziminin çalışma mekanizmasının hesaplamalı yöntemlerle belirlenmesi
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Publisher and Date:(Kadir Has Üniversitesi, 2021)DNA metilasyonu, metilasyon deseninin sürdürülmesi ve oluşturulmasından sorumlu epigenetik mekanizmalardan biridir. DNA metiltransferaz 3 (DNMT3) enzim ailesi DNA'nın sıfırdan metilasyonunu düzenler bu nedenle de novo metiltransferazlar olarak adlandırılır. İki üyesi, DNMT3A ve DNMT3B, DNA ve S-Adenosilmetiyonin (SAM) arasındaki reaksiyonu katalize eder. Diğer üyesi olan DNMT3L ise DNA ile doğrudan etkileşime girmese de, DNMT3A ve DNMT3B'ye bağlanarak reaksiyonu allosterik olarak hızlandırır. Ek ...
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Identity and Turkish Foreign Policy: The Kemalist Influence in Cyprus and the Caucasus
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Publisher and Date:(Cambridge Univ Press, 2013)
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Ideology Political Agenda and Conflict: A Comparison of American European and Turkish Legislatures' Discourses on Kurdish Question
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Publisher and Date:(Center Foreign Policy & Peace Research, 2017)Combining discourse analysis with quantitative methods this article compares how the legislatures of Turkey the US and the EU discursively constructed Turkey's Kurdish question. An examination of the legislative-political discourse through 1990 to 1999 suggests that a country suffering from a domestic secessionist conflict perceives and verbalizes the problem differently than outside observers and external stakeholders do. Host countries of conflicts perceive their problems through a more ...
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IEEE 802.15.4a Based Ultra Wideband Systems for Coexistence with Primary Users
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Publisher and Date:(IEEE, 2015)Peaceful coexistence is a major implementation issue for both cognitive radios and ultra wideband (UWB) systems. Accordingly the UWB impulse radio (UWB-IR) based Wireless Personal Area Network (WPAN) standard IEEE 802.15.4a has suggested using linear combination of pulses to limit interference to coexisting primary systems. In this paper motivated by implementing the IEEE 802.15.4a based UWB-IR systems for peaceful coexistence we consider the implementation of linear combination of pulses as ...
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IEEE 802.15.7r1 Reference Channel Models for Visible Light Communications
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Publisher and Date:(IEEE-Inst Electrical Electronics Engineers Inc, 2017)The IEEE has established the standardization group 802.15.7r1 "Short Range Optical Wireless Communications", which is currently in the process of developing a standard for visible light communication (VLC). As with any other communication system, realistic channel models are of critical importance for VLC system design, performance evaluation, and testing. This article presents the reference channel models that were endorsed by the IEEE 802.15.7r1 Task Group for evaluation of VLC system proposals. ...
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IGCP 521: “Black Sea–Mediterranean Corridor during the last 30 ka: Sea level change and human adaptation”, Istanbul, 2005
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Publisher and Date:(Elsevier Ltd, 2007)
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II. Dünya savaşından günümüze Türkiye'nin ABD ve Rusya ile siyasi ilişkileri
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Publisher and Date:(Kadir Has University, 2008)İkinci Dunya Savasindan sonra dunya siyaseti yeniden sekillenmeye baslamistir. Dunyanin iki kutba ayrilmasiyla baslayan surec zaman icerisinde mutasyonlara ugramistir. Sovyetlerin yikilmasindan sonra her seyin cok farkli olacagi dusuncesi kismen dogru cikmistir. Bu senaryoda Amerika Birlesik Devletleri ve Sovyet Sosyalist Cumhuriyetler Birligi basroldeydi. Kimileri Sovyetlerin yikilmasindan sonra boyle bir statunun tekrar ortaya cikmasinin imkansiz oldugunu dusunmustur. Ne var ki her gecen gun ...
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(Il)Legitimisation of the role of the nation state: Understanding of and reactions to Internet censorship in Turkey
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Publisher and Date:(Sage Publications Ltd, 2014)This study aims to explore Turkish citizen-consumers' understanding of and reactions to censorship of websites in Turkey by using in-depth interviews and online ethnography. In an environment where sites such as YouTube and others are increasingly being banned the citizen-consumers' macro-level understanding is that such censorship is part of a wider ideological plan and their micro-level understanding is that their relationship with the wider global network is reduced in the sense that they have ...
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Illusion or reality? The balance between security and freedom of expression in the United States and Turkey
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Publisher and Date:(International Institute of Informatics and Systemics, IIIS, 2016)Censorship is no longer limited to traditional media such as print media and TV. With the invention of Internet, the impact of censorship is felt much more strongly with regard to new media related resources of information and communication. With the escalation of terrorism in the 21stcentury, the governments all around the world have begun to use terrorist incidents as the main justification in their efforts to curb freedoms. Within this context, the primary argument of the governments in regulating ...
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Image-i-nation Africa/nation, Identity, and the Nation(s) Within
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Publisher and Date:(Brill, 2017)
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Imagining prejudice prediction models for social media research by examining the case of Venezuelan gold farmers through a neo-tribal perspective on Reddit / Reddit'te Venezuelalı altın çiftçileri hakkındaki söylemlerin neo-kabile bakış açısıyla incelenmesiyle sosyal medya araştırmalarında kullanılabilecek bir önyargı öngörü modeli tasarımı
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Publisher and Date:(Kadir Has Üniversitesi, 2021)Reddit kullanıcıların kendi çevrimiçi topluluklarını oluşturup topluluklara katılabilecekleri bir websitesidir. Kullanıcıların ilgi alanlarından oluşan bu topluluklar kendi içlerinde tartışmalar yapabilir ve bağlantılar paylaşabilirler. Reddit'in upvote/downvote mekanizması kullanıcılarına paylaşımları değerlendirip sıralama imkanı sunar, böylelikle bir subreddit'in anasayfasına bakmak kişiye en güncel konuları ve paylaşılan deneyimleri görme imkanı sağlar. Bu çevrimiçi topluluklardan biri de ...
