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  • De novo selective inhibitor design to neuronal NOS enzyme and exploration of the binding site 

    Authors:Büyüktürk, Bora
    Publisher and Date:(Kadir Has University, 2013)
    Neural Nitric Oxide Synthase (nNOS) is an enzyme that plays a significant role in neural signal transmission among brain cells by carrying on Nitric Oxide(NO) generation. nNOS is one of the member of Nitric Oxide Synthase (NOS) enzyme family and has three isoforms; nNOS, eNOS and iNOS. Since NO is a highly reactive compound, NOS isozymes have many distinct functionalities on neural, endothelial and immune systems respectively. Despite these functionalities, their binding sites show great similarities ...