Browsing by Author "Yakar, Rüya"
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Discovery of high affinity ligands for beta(2)-adrenergic receptor through pharmacophore-based high-throughput virtual screening and docking
Yakar, Rüya; Akten, Ebru Demet (Elsevier Science Inc, 2014)Novel high affinity compounds for human beta(2)-adrenergic receptor (beta(2)-AR) were searched among the clean drug-like subset of ZINC database consisting of 9928465 molecules that satisfy the Lipinski's rule of five. The ... -
Pharmacophore- based screening and docking for the discovery of novel antagonists of Beta-2 adrenergic receptor
Yakar, Rüya (Kadir Has Üniversitesi, 2013)ß2AR which is the member of rhodopsin-like GPCR is the target system for the discovery of novel antagonists using structure-based pharmacophore modeling and docking methods. initially a shared pharmacophore model is obtained ...