Browsing by KHAS Author "Uba, Abdullahi İbrahim"
Potential inhibitors of methionine aminopeptidase type II identified via structure-based pharmacophore modeling Authors:Albayati, Safana; Uba, Abdullahi İbrahim; Yelekçi, Kemal
Publisher and Date:(Springer Science and Business Media Deutschland GmbH, 2021)Methionine aminopeptidase (MetAP2) is a metal-containing enzyme that removes initiator methionine from the N-terminus of a newly synthesized protein. Inhibition of the enzyme is crucial in diminishing cancer growth and metastasis. Fumagillin—a natural irreversible inhibitor of MetAP2—and its derivatives are used as potent MetAP2 inhibitors. However, because of their adverse effects, none of them has progressed to clinical studies. In search for potential reversible inhibitors, we built structure-based ...