Browsing by Subject "c-jun N-terminal kinase"
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Electrical activity regulates AChR gene expression via JNK PKC zeta and Sp1 in skeletal chick muscle Authors:
Publisher and Date:(Elsevier Science Bv, 2001)Electrical activity of myotubes represses nicotinic acetylcholine receptor (AChR) gene expression. This effect is mimicked by okadaic acid and blocked by tetrodotoxin (TTX) or staurosporine in cultured myocytes [Altiok et al. EMBO J. 16 (1997) 717-725]. In this study we investigated the mechanism of this repression. We show that addition of exogenous phospholipase D (PLD) and C inhibits AChR expression in a manner which parallels that of okadaic acid. Furthermore okadaic acid caused an increase ...
Simvastatin induces proliferation inhibition and apoptosis in C6 glioma cells via c-jun N-terminal kinase Authors:
Publisher and Date:(Elsevier Ireland Ltd., 2004)The lipid-lowering drugs statins induce apoptosis in a variety of tumor cells. Here we investigated the apoptotic effect of the lipophilic statin simvastatin in C6 glioma cells and the underlying effects on intracellular signal transduction. Simvastatin inhibited cell proliferation totally after 20 h of treatment as shown by the decrease in proliferating cell nuclear antigen expression in the nucleus. Subsequently simvastatin caused apoptotic cell death by shrinkage of cytoplasm and condensation ...