Browsing Bilgisayar Mühendisliği / Computer Engineering by KHAS Author "Abaka, Gamze"
CAMPways: constrained alignment framework for the comparative analysis of a pair of metabolic pathways Authors:Abaka, Gamze; Biyikoglu, Turker; Erten, Cesim
Publisher and Date:(Oxford University Press, 2013)Motivation: Given a pair of metabolic pathways an alignment of the pathways corresponds to a mapping between similar substructures of the pair. Successful alignments may provide useful applications in phylogenetic tree reconstruction drug design and overall may enhance our understanding of cellular metabolism. Results: We consider the problem of providing one-to-many alignments of reactions in a pair of metabolic pathways. We first provide a constrained alignment framework applicable to the problem. ...