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Synthesis Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors 

Coşkun, Göknil Pelin; Djikic, Teodora; Hayal, Taha Bartu; Turkel, Nezaket; Yelekçi, Kemal; Sahin, Fikrettin; Küçükgüzel, Şükriye Güniz (MDPI, 2018)
Cyclooxygenase enzymes play a vital role in inflammatory pathways in the human body. Apart from their relation with inflammation the additional involvement of COX-2 enzyme with cancer activity was recently discovered. In ...
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Synthesis anticancer activity and molecular modeling of etodolac-thioether derivatives as potent methionine aminopeptidase (type II) inhibitors 

Çoruh, Işıl; Çevik, Ozge; Yelekçi, Kemal; Djikic, Teodora; Küçükgüzel, Şükriye Güniz (Wiley, 2018)
A series of (RS)-1-{[5-(substituted)sulfanyl-4-substituted-4H-124-triazole-3-yl]methyl}-18-diethyl-1349-tetrahydropyrano[34-b]indoles (5a-v) were designed and synthesized using a five-step synthetic protocol that involves ...
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Synthesis molecular modeling in vivo study and anticancer activity of 124-triazole containing hydrazide-hydrazones derived from (S)-naproxen 

Han, Muhammed İhsan; Bekçi, Hatice; Uba, Abdullahi İbrahim; Yıldırım, Yeliz; Karasulu, Ercüment; Cumaoğlu, Ahmet; Karasulu, Hatice Y.; Yelekçi, Kemal; Yılmaz, Ozguer; Küçükgüzel, Şükriye Güniz (Wiley-VCH Verlag GmbH, 2019)
A new series of 124-triazole containing hydrazide-hydrazones derived from (S)-naproxen (7a-m) was synthesized in this study. The structures of these compounds were characterized by spectral (Fourier-transform infrared ...
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Synthesis Molecular Modelling and Antibacterial Activity Against Helicobacter pylori of Novel Diflunisal Derivatives as Urease Enzyme Inhibitors 

Coşkun, Göknil Pelin; Djikic, Teodora; Kalaycı, Sadık; Yelekçi, Kemal; Şahin, Fikrettin; Küçükgüzel, Şükriye Güniz (Bentham Science Publ Ltd, 2019)
Background: The main factor for the prolongation of the ulcer treatment in the gastrointestinal system would be Helicobacter pylori infection which can possibly lead to gastrointestinal cancer. Triple therapy is the treatment ...

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Kucukguzel S. Guniz (4)
Yelekci Kemal (4)
Djikic, Teodora (3)Coşkun, Göknil Pelin (2)Bekci Hatice (1)Cumaoglu Ahmet (1)Han Muhammed I. (1)Hayal, Taha Bartu (1)Kalaycı, Sadık (1)Karasulu Ercuement (1)... View MoreSubjectDiflunisal (2)Molecular docking (2)Thiosemicarbazide (2)(S)-naproxen (1)124-triazole (1)124-triazole-3-thione (1)124-triazole-3-thiones (1)Anticancer (1)Anticancer activity (1)Apoptosis (1)... View MoreDate Issued2018 (2)2019 (2)Has File(s)false (3)true (1)

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