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dc.contributor.authorKoyutürk, Meral
dc.contributor.authorTunali, Sevim
dc.contributor.authorBolkent, Şehnaz
dc.contributor.authorYanardağ, Refiye
dc.date.accessioned2019-06-27T08:00:52Z
dc.date.available2019-06-27T08:00:52Z
dc.date.issued2005
dc.identifier.issn0163-4984
dc.identifier.urihttps://hdl.handle.net/20.500.12469/129
dc.identifier.urihttps://dx.doi.org/10.1385/BTER:104:3:233
dc.description.abstractThe aim of this study was to investigate the microscopic and biochemical effects of vanadyl sulfate on liver tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. Degenerative changes were observed in diabetic animals by light and transmission electron microscopes. Although there were individual differences in diabetic animals to which vanadium was given some reduction of degenerative changes were detected. After 60 d of treatment serum aspartate and alanine transaminase alkaline phosphatase blood glucose levels liver lipid peroxidation and nonenzymatic glycosylation significantly increased but liver glutathione levels significantly decreased in the diabetic group. On the other hand treatment with vanadyl sulfate reversed these effects. As a result it might be concluded that vanadyl sulfate has a protective effect on damage of liver of streptozotocin-induced diabetic rats.
dc.language.isoEnglish
dc.publisherHumana Press Inc.
dc.subjectStreptozotocin
dc.subjectLiver tissue
dc.subjectVanadyl sulfate
dc.subjectLight microscopy
dc.subjectElectron microscopy
dc.subjectBiochemistry
dc.titleEffects of vanadyl sulfate on liver of streptozotocin-induced diabetic rats
dc.typeArticle
dc.identifier.startpage233
dc.identifier.endpage247
dc.relation.journalBiological Trace Element Research
dc.identifier.issue3
dc.identifier.volume104
dc.identifier.wosWOS:000230354900005
dc.identifier.doi10.1385/BTER:104:3:233


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