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dc.contributor.authorAk, Duygu Gezen
dc.contributor.authorKahraman, Hakkı
dc.contributor.authorDursun, Erdinç
dc.contributor.authorDuman, Belgin Süsleyici
dc.contributor.authorErensoy, Nevin
dc.contributor.authorAlagöl, Faruk
dc.contributor.authorTanakol, Refik
dc.contributor.authorYilmazer, Selma
dc.date.accessioned2019-06-27T08:00:53Z
dc.date.available2019-06-27T08:00:53Z
dc.date.issued2005
dc.identifier.issn0278-0240en_US
dc.identifier.issn1875-8630en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12469/138
dc.identifier.urihttps://doi.org/10.1155/2005/645260
dc.description.abstractVitamin D receptor (VDR) gene polymorphisms have been suggested as possible determinants of bone mineral density (BMD) and calcium metabolism. In this study our aim was to determine whether there is an association between VDR gene polymorphism and osteomalacia or not. We determined ApaI and TaqI polymorphisms in the vitamin D receptor gene in 24 patients with osteomalacia and 25 age-matched healthy controls. Serum calcium phosphorus ALP PTH 25OHD levels were also examined. We used PCR and RFLP methods to test for an association between osteomalacia and polymorphisms within intron 8 and exon 9 of the VDR gene. When the control and patients were compared for their ApaI and TaqI genotypes there was no relationship between VDR gene allelic polymorphisms and osteomalacia. Whereas a nearly significant difference for A allele was found in the allellic distribution of the patients (p=0.08). Also no association between biochemical data and VDR gene polymorphisms was observed.en_US]
dc.language.isoengen_US
dc.publisherHindawi Ltden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVitamin Den_US
dc.subjectOsteomalaciaen_US
dc.subjectVitamin D receptor geneen_US
dc.subjectApaIen_US
dc.subjectTaqIen_US
dc.titlePolymorphisms at the ligand binding site of the vitamin D receptor gene and osteomalaciaen_US
dc.typearticleen_US
dc.identifier.startpage191en_US
dc.identifier.endpage197
dc.relation.journalDisease Markersen_US
dc.identifier.issue4
dc.identifier.volume21en_US
dc.identifier.wosWOS:000235915800004en_US
dc.identifier.doi10.1155/2005/645260en_US
dc.identifier.scopus2-s2.0-30444443813en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid16403954en_US


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