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dc.contributor.authorDuman, Belgin Süsleyici
dc.contributor.authorTanakol, Refik
dc.contributor.authorErensoy, Nevin
dc.contributor.authorOzturk, Melek
dc.contributor.authorYilmazer, Selma
dc.date.accessioned2019-06-27T08:00:56Z
dc.date.available2019-06-27T08:00:56Z
dc.date.issued2004
dc.identifier.issn1011-7571
dc.identifier.issn1423-0151
dc.identifier.urihttps://hdl.handle.net/20.500.12469/167
dc.identifier.urihttps://dx.doi.org/10.1159/000079524
dc.description.abstractObjective: Vitamin D receptor (VDR) gene polymorphisms and bone metabolic markers were investigated as potential genetic markers for osteoporosis in postmenopausal Turkish women. The relationship between their VDR gene polymorphisms and bone states was determined. Materials and Methods: Restriction fragment length polymorphisms at the VDR gene locus (i.e. for BsmI ApaI and TaqI) was investigated in 75 postmenopausal osteoporotic (53.16+/-1.31 years) and 66 healthy (52.62+/-1.69 years) Turkish women and the genotypes were related to bone mineral density (BMD) at femoral neck (FN) lumbar spine (L1-4) trochanter Ward's triangle (Ward's) and metabolic parameters of bone turnover. Results: In osteoporotic women TaqI genotype-related differences of the VDR gene were found to be significant at all BMD sites
dc.description.abstractTT genotype had higher L1-4 BMD values than Tt and tt (p<0.05)
dc.description.abstracttt genotype had significantly lower BMD at FN (p<0.05) trochanter (p<0.01) and Ward's (p<0.05) compared to TT genotype. The tt genotype was found to be associated with higher (p<0.05) serum osteocalcin levels compared to Tt and TT genotypes in the osteoporotic women whereas no such association was found for the healthy women. Conclusion: Our data showed an association between VDR TaqI genotype and BMD at the FN L1-4 trochanter and Ward's triangle in nonobese postmenopausal osteoporotic women. Thus the VDR gene TaqI polymorphism modulates differences in BMD in the postmenopausal osteoporotic women. Copyright (C) 2004 S. Karger AG Basel.
dc.language.isoEnglish
dc.publisherKARGER
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbone mineral density
dc.subjectvitamin D receptor gene polymorphism
dc.subjectosteoporosis
dc.subjectmenopause
dc.titleVitamin D receptor alleles bone mineral density and turnover in postmenopausal osteoporotic and healthy women
dc.typeArticle
dc.identifier.startpage260
dc.identifier.endpage266
dc.relation.journalMedical Principles and Practice
dc.identifier.issue5
dc.identifier.volume13
dc.identifier.wosWOS:000223490600005
dc.identifier.doi10.1159/000079524


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