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dc.contributor.authorOzturk, Levent
dc.contributor.authorUnal, Murat
dc.contributor.authorTamer, Lülüfer
dc.contributor.authorCelikoglu, Firuz
dc.date.accessioned2019-06-27T08:00:57Z
dc.date.available2019-06-27T08:00:57Z
dc.date.issued2003
dc.identifier.issn0886-4470
dc.identifier.urihttps://hdl.handle.net/20.500.12469/184
dc.identifier.urihttps://dx.doi.org/10.1001/archotol.129.5.538
dc.description.abstractObjective: To examine whether circulating leptin levels correlate with the severity of disease in patients with obstructive sleep apnea. Design: Prospective nonrandomized study. Setting: Referral sleep laboratory for patients with sleep-disordered breathing and biochemistry laboratory. Patients: Thirty-two subjects (mean+/-SD age 47+/-12 years) who were referred for suspected sleep apnea underwent an overnight sleep study and fasting morning venous blood sampling. Patients were divided into 3 groups with respect to apnea-hypopnea index: (1) severe sleep apnea (n=8) apnea-hypopnea index greater than 20
dc.description.abstract(2) mild sleep apnea (n=12) apnea-hypopnea index between 5 and 20
dc.description.abstractand (3) nonapneic control (n=12) apnea-hypopnea index less than 5. Results: Leptin levels (mean+/-SD) were 21.2+/-8.6 16.2+/-5.2 and 10.6+/-7.5 ng/mL (P=.005) inpatients with severe and mild obstructive sleep apnea and nonapneic controls respectively. Plasma leptin levels correlated positively with the degree of sleep-disordered breathing as recorded by the apnea-hypopnea index (r=0. 54 P=.001) and percentage of sleep time spent with oxygen saturation below 90% (r=0.39 P=.02). Conclusions: Circulating leptin concentrations in patients with obstructive sleep apnea independent of body mass index and age are significantly higher than levels in nonapneic controls and there is a positive relationship between leptin concentrations and the severity of sleep apnea. Hyperleptinemia may be a prognostic marker of obstructive sleep apnea syndrome.
dc.language.isoEnglish
dc.publisherAmer Medical Assoc.
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe association of the severity of obstructive sleep apnea with plasma leptin levels
dc.typeArticle
dc.identifier.startpage538
dc.identifier.endpage540
dc.relation.journalArchives of Otolaryngology-Head & Neck Surgery
dc.identifier.issue5
dc.identifier.volume129
dc.identifier.wosWOS:000182756300004
dc.identifier.doi10.1001/archotol.129.5.538


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