Browsing Araştırma Çıktıları / TR Dizin by Author "Tatar, Gamze Bora"
Power of inhibition activity screening and 3D molecular modeling approaches in HDAC 8 inhibitor design Authors:Tatar, Gamze Bora; Tokluman, Tenzile Deniz; Yelekçi, Kemal; Yurter, Hayat
Publisher and Date:(Scientific Technical Research Council Turkey-Tubitak, 2011)In-vitro inhibition activity screening and in-silico 3D molecular modeling approaches are important tools for design and development of specific histone deacetylase (HDAC) inhibitors. The objective of this study was to investigate the consistency between these 2 approaches. The HDAC 8 inhibition activities of 8 randomly selected different carboxylic acid derivatives were screened and in-vitro experimental results were compared with in-silico molecular modeling calculations. This study demonstrated ...