Araştırma Çıktıları / PubMed
Recent Submissions
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Complete density calculations of q-state Potts and clock models: Reentrance of interface densities under symmetry breaking
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Publisher and Date:(Amer Physical Soc, 2020)All local bond-state densities are calculated for q-state Potts and clock models in three spatial dimensions, d = 3. The calculations are done by an exact renormalization group on a hierarchical lattice, including the density recursion relations, and simultaneously are the Migdal-Kadanoff approximation for the cubic lattice. Reentrant behavior is found in the interface densities under symmetry breaking, in the sense that upon lowering the temperature, the value of the density first increases and ...
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On the uniqueness of epidemic models fitting a normalized curve of removed individuals
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Publisher and Date:(Springer Heidelberg, 2015)The susceptible-infected-removed (SIR) and the susceptible-exposed-infected-removed (SEIR) epidemic models with constant parameters are adequate for describing the time evolution of seasonal diseases for which available data usually consist of fatality reports. The problems associated with the determination of system parameters starts with the inference of the number of removed individuals from fatality data, because the infection to death period may depend on health care factors. Then, one ...
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Design, Synthesis and hMAO Inhibitory Screening of Novel 2-Pyrazoline Analogues
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Publisher and Date:(Bentham Science Publ Ltd, 2017)Aim and Objective: MAO inhibitors have a significant effect on the nervous system since they act in regulation of neurotransmitter concentrations. Neurotransmitter levels are critical for a healthy nervous system. MAO inhibitors can be used in the treatment of neurological disorders such as depression, Parkinson's disease and Alzheimer's disease, as the increase or decrease of some neurotransmitter concentrations is associated with these neurological disorders. This study was conducted to discover ...
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Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6
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Publisher and Date:(Elsevier Sci Ltd, 2018)Histone deacetylase (HDAC) 6 plays a role in oncogenic transformation and cancer metastasis via tubulin deacetylation, making it a critical target for anticancer drug design. However, lack of selectivity shown by many of the current HDAC6 inhibitors in clinical use and trials prompts the continuous search for selective inhibitors. Here, 10 pharmacophore hypotheses were developed based on the 3D common features of training set of 20 HDAC inhibitors in clinical use and trials. The hypotheses were ...
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Post-synthetically elaborated BODIPY-based porous organic polymers (POPs) for the photochemical detoxification of a sulfur mustard simulant
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Publisher and Date:(American Chemical Society, 2020)Designing new materials for the effective detoxification of chemical warfare agents (CWAs) is of current interest given the recent use of CWAs. Although halogenated borondipyrromethene derivatives (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene or BDP or BODIPY) at the 2 and 6 positions have been extensively explored as efficient photosensitizers for generating singlet oxygen (1 O2) in homogeneous media, their utilization in the design of porous organic polymers (POPs) has remained elusive due to the ...
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Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives
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Publisher and Date:(Elsevier Masson s.r.l., 2020)In this study, (S)-naproxen thiosemicarbazides (3a-d), 1,2,4-triazoles (4a-c), triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d, 4a and 5a-p) were confirmed by FT-IR, 1H NMR,13C NMR, HR-Mass spectra and elemental analysis. These compounds are designed to inhibit methionine amino peptidase-2 (MetAP2) enzyme in prostate cancer. These compounds (3d, 5a-p) evaluated against androgen-independent prostate adenocarcinoma (PC-3, DU-145) and androgen-dependent ...
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Cognitive styles and religion
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Publisher and Date:(Elsevier B.V., 2021)I discuss recent research suggesting that individual differences in cognitive style give rise to and explain religious and related supernatural and paranormal beliefs. To do so, I illustrate intuitive cognitive biases (e.g., anthropomorphism) underlying these beliefs and then review the accumulated evidence indicating that non-believers are more open-minded, reflective, and less susceptible to holding epistemically suspect beliefs (e.g., conspiracy theories) on average than those who believe in ...
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What Can We Estimate From Fatality and Infectious Case Data Using the Susceptible-Infected-Removed (SIR) Model? A Case Study of Covid-19 Pandemic
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Publisher and Date:(Frontıers Medıa Sa, 2020)The rapidly spreading Covid-19 that affected almost all countries, was first reported at the end of 2019. As a consequence of its highly infectious nature, countries all over the world have imposed extremely strict measures to control its spread. Since the earliest stages of this major pandemic, academics have done a huge amount of research in order to understand the disease, develop medication, vaccines and tests, and model its spread. Among these studies, a great deal of effort has been invested ...
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Across dimensions: Two- and three-dimensional phase transitions from the iterative renormalization-group theory of chains
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Publisher and Date:(2020)Sharp two- and three-dimensional phase transitional magnetization curves are obtained by an iterative renormalization-group coupling of Ising chains, which are solved exactly. The chains by themselves do not have a phase transition or nonzero magnetization, but the method reflects crossover from temperaturelike to fieldlike renormalization-group flows as the mechanism for the higher-dimensional phase transitions. The magnetization of each chain acts, via the interaction constant, as a magnetic ...
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Adoption of Mobile Health Apps in Dietetic Practice: Case Study of Diyetkolik
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Publisher and Date:(Jmır Publıcatıons, Inc, 130 Queens Quay E, 2020)Background: Dietetics mobile health apps provide lifestyle tracking and support on demand. Mobile health has become a new trend for health service providers through which they have been shifting their services from clinical consultations to online apps. These apps usually offer basic features at no cost and charge a premium for advanced features. Although diet apps are now more common and have a larger user base, in general, there is a gap in literature addressing why users intend to use diet apps. ...
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The role of co-regulation of stress in the relationship between perceived partner responsiveness and binge eating: A dyadic analysis
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Publisher and Date:(International Union of Psychological Science, 2020)The main aim of this study is to investigate whether there are relationships between perceived partner responsiveness (PPR), co-regulation of negative affect between romantic partners and binge eating. Data were collected from 148 opposite-sex romantic partners (18-61 years old) with the mean relationship duration being 8.04 years. Dyadic data were analysed through the actor-partner interdependence model framework. We proposed a model where co-regulation between partners has indirect effects on ...
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Facial autologous soft-tissue contouring by adjunction of tissue cocktail injection (micrograft and minigraft mixture of dermis, fascia, and fat)
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Publisher and Date:(2000)Facial aging is both a physiologic and anatomic process characterized by changes in the skin and supporting tissues. The aging process produces an outer envelope that gradually expands while its contents gradually involute and the underlying structure weakens. This process results in an excess of skin that tends to create folds, grooves, and deepening furrows. Contour augmentation and filling depressions with autologous tissue or heterogeneous materials are widely used in face rejuvenation as an ...
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[The effects of phase II cardiac rehabilitation programme on patients undergone coronary bypass surgery]
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Publisher and Date:(2005)Objective: To investigate the effects of phase II cardiac rehabilitation in 52 patients undergone coronary artery bypass surgery. Methods: Gradual walking tests, cardio-pulmonary capacity tests and lipid profile were administered to patients selected for phase II cardiac rehabilitation before and after the programme. Training was started on 12-channel electrocardiogram controlled running bands 3 times a week for 20 min periods for 12 weeks fitting the programme. Low or intermediate level exercise ...
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Brow suspension, a minimally invasive technique in facial rejuvenation
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Publisher and Date:(2002)People tend to prefer noninvasive or minimally invasive methods of facial rejuvenation, especially when it involves their face, which is the hallmark of a person's identity and impossible to hide. It is widely known that brow ptosis gives the face a "tired look" and also accentuates deformities of the upper eyelid. Most people who are interested in facial rejuvenation may not accept even a minor surgery, such as an endoscopic surgery. The senior author has developed a minimally invasive method of ...
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Women's shelters in Turkey: a qualitative study on shortcomings of policy making and implementation
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Publisher and Date:(2013)Despite a long history of women's movements and policy-making efforts to ameliorate women's status in Turkey, the number and quality of women's shelters are far from sufficient. This article aims to reveal the shortcomings of shelter policy through the lens of those "at work" on this important social issue using a qualitative research design. Forty semistructured in-depth interviews were conducted with municipal administrative officials, state social workers, and employees of civil society ...
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New Human Monoamine Oxidase A Inhibitors with Potential Anti- Depressant Activity: Design, Synthesis, Biological Screening and Evaluation of Pharmacological Activity
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Publisher and Date:(Bentham Science, 2017)Aim and objective: Depression is a momentous disease that can greatly reduce the quality of life and cause death. In depression, neurotransmitter levels such as serotonine, dopamine and noradrenaline are impaired. Monoamine oxidases (MAO) are responsible for oxidative catalysis of these monoamine neurotransmitters. Because of this relation, MAO-A inhibitors show antidepressant activity by regulating neurotransmitter levels. This study was carried out to investigate the design, synthesis and activity ...
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Crystallographic structure versus homology model: a case study of molecular dynamics simulation of human and zebrafish histone deacetylase 10
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Publisher and Date:(Taylor & Francis, 2020)Histone deacetylase (HDAC) 10 has been implicated in the pathology of various cancers and neurodegenerative disorders, making the discovery of novel inhibitors of the isoform an important endeavor. However, the unavailability of crystallographic structure of human HDAC10 (hHDAC10) hinders structure-based drug design effort. Previously, we reported the homology modeled structure of human HDAC10 built using the crystallographic structure of Danio rerio (zebrafish) HDAC10 (zHDAC10) (Protein Data Bank ...
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The acquisition and use of relative clauses in Turkish-learning children's conversational interactions: a cross-linguistic approach
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Publisher and Date:(Cambridge University Press, 2019)Using a cross-linguistic approach, we investigated Turkish-speaking children's acquisition and use of relative clauses (RCs) by examining longitudinal child-caregiver interactions and cross-sectional peer conversations. Longitudinal data were collected from 8 children between the ages of 8 and 36 months. Peer conversational corpus came from 78 children aged between 43 and 64 months. Children produced RCs later than in English (Diessel, 2004) and Mandarin (Chen & Shirai, 2015), and demonstrated ...
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Synthesis, biological evaluation and molecular docking studies of bis-chalcone derivatives as xanthine oxidase inhibitors and anticancer agents
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Publisher and Date:(Elsevier, 2019)In this study, a series of B-ring fluoro substituted bis-chalcone derivatives were synthesized by Claisen-Schmidt condensation reactions and evaluated for their ability to inhibit xanthine oxidase (XO) and growth inhibitory activity against MCF-7 and Caco-2 human cancer cell lines, in vitro. According to the results obtained, the bis-chalcone with fluoro group at the 2 (4b) or 2,5-position (4g) of B-ring were found to be potent inhibitors of the enzyme with IC50 values in the low micromolar range. ...
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