Browsing by Author "Yelekçi, Kemal"
Now showing items 41-60 of 82
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In silico designing of isoform-selective inhibitors against class IIA histone deacetylases
Elmezayen, Ammar Dawoud Ahmed Mahmoud (Kadir Has Üniversitesi, 2021)The fundamental cause of human cancer is strongly influenced by down- or upregulations of epigenetic factors. Upregulated histone deacetylases (HDAC) have been shown to be effectively neutralized by the action of HDACs ... -
In silico identification of novel and selective monoamine oxidase B inhibitors
Yelekçi, Kemal; Büyüktürk, Bora; Kayrak, Nurdan (SPRINGER WIEN, 2013)Monoamine oxidases (MAO) A and B are flavin adenine dinucleotides containing enzymes bound to the mitochondrial outer membranes of the cells of the brain liver intestine and placenta as well as platelets. Recently selective ... -
In silico identification of physiological substrates and inhibitors of serum paraoxonase 1 enzyme
Karabıyık, Talha (Kadir Has Üniversitesi, 2014)Paraoxonase 1 (PON1) as an important antioxidant enzyme against oxidative stress has been implicated in the pathogenesis of a number of disorders including cancer cardiovascular and several other diseases. Although there ... -
In Silico Inhibitor Design For Monomine Oxidase A And B Isozymes
Mıdık, Çağla (Kadir Has Üniversitesi, 2012)in this thesis study MAO-A and MAO-B isozymes are selected as target enzymes that have important role of regulation of diseases such as ..Parkinson Alzheimer and depression... MAO isozymes which catalyze the oxidation of ... -
In silico modeling of dopamine transporter and design of novel neuroprotective drugs for Parkinson's disease
Dikic, Teodora (Kadir Has Üniversitesi, 2017)Parkinson hastalıgı (PH), substantia nigra (SN) ve corpus striatum (CS) bolgelerinde dopamin ureten noronların kaybedilmesi ile karakterize edilen bir olgudur. Yaygın olarak uygulanan tedavi dopamin noronlarının kaybolmalarının ... -
In silico screening of multi target drug for alzheimer'sdisease and parkinson's disease using pharmacophore-baseddrug discovery approach
Raji, Sarah Mohammed Jaafar (Kadir Has Üniversitesi, 2019)Research on neurodegenerative diseases (NDD), commonly known as Alzheimer's and Parkinson's disease are the most important concern in this aging society. Among the other causes the main suspected reasons are the production ... -
In silico screening of neuronal nitric oxide synthase enzyme inhibitors
Örtmen, Bahanur (Kadir Has Üniversitesi, 2014)Three closely related isoforms of nitric oxide synthases (NOS) catalyze an important secondary messenger nitric oxide (NO) synthesis through oxidation of L-arginine to L-citrulline. These three NOS isoforms takes parts in ... -
In silico screening of potent histon demethylase1 (lsd1) enzyme inhibitor
TAHER AL-RIKABI, MARYAM MUHSIN (Kadir Has Üniversitesi, 2020)Histone lysine specific demethylase (LSD1) is one of the main enzymes which regulates histone demethylation which in return regulates different epigenetic processes such DNA replication and transcription also gene silencing. ... -
In silico screening of potent HIV-1 integrase inhibitors for the treatment of human immunodeficiency virus (HIV)
Samorlu, Augustine (Kadir Has Üniversitesi, 2018)Bu araştırmanın amacı, AIDS olarak bilinen insan bağışıklık sistemine etki eden, duraksamayan ve depresif bir hastalığa neden olan HIV-1'in tedavisi için potansiyel inhibitörleri elde etmektir. HIV-1 integraz inhibitörleri, ... -
In silico screening of potential peroxisome proliferator-activated receptors (Alpha-gamma) ppars ?/? for the treatment of human diabetic mellitus (DM)
ABDULJABBAR, Farah Ismael (Kadir Has Üniversitesi, 2020)Diabetes mellitus (DM) means a metabolic ailment identified by hyperglycemia, obesity, hypertension, which can contribute to the metabolic disturbances on sugars, lipids, and protein. PPARα and PPARγ become signified the ... -
In silico screening of tangible-potential inhibitor of methionine aminopeptidase 2 for the treatment of cancer
Weako, Jackson (Kadir Has Üniversitesi, 2017)Methionine Aminopeptidases (MetAPs) are divalent-cofactor dependent enzymes that are responsible for cleaving the initiator Methionine from the newly synthesized polypeptides. These metalloproteases are classified into two ... -
Insights into the binding mode of new N-substituted pyrazoline derivatives to MAO-A: docking and quantum chemical calculations
Erdem, Safiye Sag; Turkkan, Seyhan; Yelekçi, Kemal; Gokhan-Kelekçi, Nesrin (SPRINGER WIEN, 2013)The binding modes of four N-substituted pyrazoline derivatives as novel MAO-A inhibitory agents were investigated using docking and quantum chemical molecular modelling tools. -
Intermolecular interactions in human HDAC8 crystal structures and the stability of binding modes of co-crystallized inhibitors
Yelekçi, Kemal; Uba, Abdullahi Ibrahim (Amer Chemical Soc, 2019)[Abstract Not Available] -
MEDI 333-Histone deacetylase inhibition activity of resveratrol and its analogs
Dayangac-Erden, Didem; Ayhan, Peruze; Bora, Gamze; Yelekçi, Kemal; Dalkara, Sevim; Demir, Ayhan S.; Erdem-Yurter, Hayat (Amer Chemical Soc, 2007)[Abstract Not Available] -
Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies
Bora-Tatar, Gamze; Dayangac-Erden, Didem; Demir, Ayhan S.; Dalkara, Sevim; Yelekçi, Kemal; Erdem-Yurter, Hayat (Pergamon-Elsevier Science Ltd, 2009)In the light of known HDAC inhibitors 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop the structure-activity ... -
Monoamin oksidaz (MAO) inhibitör etkili yeni prazolin türevlerinin moleküler modelleme yöntemiyle tasarlanması, sentezi ve inhibisyon kinetiklerinin hesapsal ve deneysel olarak tayini
Salgın, Umut Gökşen; Erdem, Ayşe; Gökhan, Nesrin Kelekçi; Erdem, Safiye; Türkkan, Seyhan; Yelekçi, Kemal; Uçar, Gülberk (2010)[Abstract Not Available] -
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors
Salgın-Göksen, Umut; Telli, Gökçen; Erikci, Açelya; Dedecengiz, Ezgi; Tel, Banu Cahide; Kaynak, F. Betül; Yelekçi, Kemal; Ücar, Gülberk; Gökhan-Kelekçi, Nesrin (AMER CHEMICAL SOC, 2021-02)Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3,5-disubstitutedphenyl-2-pyrazoline structure and nine compounds having N'-(1,3-disubstitutedphenylallylidene)-2-(5-substituted- 2-benzoxazolin ... -
New Human Monoamine Oxidase A Inhibitors with Potential Anti- Depressant Activity: Design, Synthesis, Biological Screening and Evaluation of Pharmacological Activity
Evranos Aksöz, Begüm; Uçar, Gülberk; Taş, Sadık Taşkın; Aksöz, Erkan; Yelekçi, Kemal; Erikçi, Açelya; Sara, Yıldırım; İskit, Alper Bektaş (Bentham Science, 2017)Aim and objective: Depression is a momentous disease that can greatly reduce the quality of life and cause death. In depression, neurotransmitter levels such as serotonine, dopamine and noradrenaline are impaired. Monoamine ... -
New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: Synthesis biological evaluation and structural determinants of MAO-A and MAO-B selectivity
Gökhan-Kelekçi, Nesrin; Koyunoğlu, Semra; Yabanoğlu-Çiftçi, Samiye; Yelekçi, Kemal; Özgen, Özen; Uçar, Gülberk; Erol, Kevser; Kendi, Engin; Yeşilada, Akguel (Pergamon-Elsevier Science Ltd, 2009)A new series of pyrazoline derivatives were prepared starting from a quinazolinone ring and evaluated for antidepressant anxiogenic and MAO-A and -B inhibitory activities by in vivo and in vitro tests respectively. Most ... -
De novo selective inhibitor design to neuronal NOS enzyme and exploration of the binding site
Büyüktürk, Bora (Kadir Has Üniversitesi, 2013)Neural Nitric Oxide Synthase (nNOS) is an enzyme that plays a significant role in neural signal transmission among brain cells by carrying on Nitric Oxide(NO) generation. nNOS is one of the member of Nitric Oxide Synthase ...