Browsing Tez Koleksiyonu by Author "Akdoğan, Ebru Demet"
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Investigation of allosteric inhibition effect in pyruvate kinase by constrained molecular dynamics simulation method Piruvat kinazın allosterik olarak inhibe edilmesinin kısıtlanmış moleküler dinamik similasyon methodu kullanılarak incelenmesi
Akkaya, Reyhan (Kadir Has Üniversitesi, 2021)In previous studies, our research group identified species-specific allosteric sites in glycolytic enzymes from different organisms and identified candidate inhibitory molecules that strongly interact with the residues at ... -
Pharmacophore- based screening and docking for the discovery of novel antagonists of Beta-2 adrenergic receptor
Yakar, Rüya (Kadir Has Üniversitesi, 2013)ß2AR which is the member of rhodopsin-like GPCR is the target system for the discovery of novel antagonists using structure-based pharmacophore modeling and docking methods. initially a shared pharmacophore model is obtained ... -
The prediction of 3d structure of the dimeric state of human β2-adrenergic receptor
Koroğlu, Ayça (Kadir Has Üniversitesi, 2016)A significant amount of experimental and computational data points out a possible role of TM6 in the dimerization of ?2-adrenergic receptor (?2AR). Peptide– and protein–protein docking experiments guided by this assumption ...