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Phase transitions between different spin-glass phases and between different chaoses in quenched random chiral systems
(Amer Physical Soc., 2017)
The left-right chiral and ferromagnetic-antiferromagnetic double-spin-glass clock model with the crucially even number of states q = 4 and in three dimensions d = 3 has been studied by renormalization-group theory. We find ...
RedNemo: topology-based PPI network reconstruction via repeated diffusion with neighborhood modifications
(Oxford University Press, 2017)
Motivation: Analysis of protein-protein interaction (PPI) networks provides invaluable insight into several systems biology problems. High-throughput experimental techniques together with computational methods provide ...
"It was as if society didn't want a woman to get an abortion": a qualitative study in Istanbul Turkey
(Elsevier Science Inc, 2017)
Introduction: In 1983 abortion without restriction as to reason was legalized in Turkey. However at an international conference in 2012 the Prime Minister condemned abortion and announced his intent to draft restrictive ...
The availability of abortion at state hospitals in Turkey: A national study
(Elsevier, 2017)
Introduction: Abortion in Turkey has been legal since 1983 and remains so today. Despite this in 2012 the Prime Minister declared that in his opinion abortion was murder. Since then there has been growing evidence that ...
Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: a combined approach of structure-based virtual screening ADMET prediction and molecular dynamics simulation assay
(Taylor & Francis Inc, 2018)
Histone deacetylases (HDACs) have gained increased attention as targets for anticancer drug design and development. HDAC inhibitors have proven to be effective for reversing the malignant phenotype in HDAC-dependent cancer ...
Intrinsic Dynamics and Causality in Correlated Motions Unraveled in Two Distinct Inactive States of Human beta(2)-Adrenergic Receptor
(Amer Chemical Soc, 2019)
The alternative inactive state of the human beta(2)-adrenergic receptor originally exposed in molecular dynamics simulations was investigated using various analysis tools to evaluate causality between correlated residue-pair ...
Ligand-binding affinity of alternative conformers of human beta(2)-adrenergic receptor in the presence of intracellular loop 3 (ICL3) and their potential use in virtual screening studies
(Wiley, 2019)
This study investigates the structural distinctiveness of orthosteric ligand-binding sites of several human beta(2) adrenergic receptor (beta(2)-AR) conformations that have been obtained from a set of independent molecular ...
Psychosocial interventions to improve outcomes among dialysis patients
(Wiley, 2018)
Patients with end-stage renal disease (ESRD) report high levels of emotional problems and poor compliance with treatment and quality of life. Nevertheless there are not many studies which examine the effectiveness of ...
Factors that influence attitude and enforcement of the smoke-free law in Turkey: a survey of hospitality venue owners and employees
(Bmj Publishing Group, 2017)
Introduction In 2009 Turkey extended the smoke-free legislation to hospitality venues. Compliance however remains low in some hospitality venues. We identified characteristics associated with knowledge of health effects ...
New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes
(Company of Biologists Ltd, 2017)
Cytoplasmic FMRP interacting protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID) autism schizophrenia and epilepsy. It is a member of a family of proteins that is highly conserved during evolution sharing ...