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The interrelationship between insulin secretion and action in Type 2 diabetes mellitus with different degrees of obesity: Evidence supporting central obesity
(Editrice Kurtis S R L, 2003)
This paper investigates the relative role of the impairment of insulin secretion and action in the pathogenesis of Type 2 diabetes mellitus (T2DM). The parameters indicating insulin secretion and action were calculated ...
Reconstruction of the superior labial sulcus in secondary bilateral cleft lip deformities: An inverted U-shaped flap
(Lippincott Williams & Wilkins, 2001)
A shallow buccal sulcus deformity following bilateral cleft lip repair is not rare. A variety of techniques are described for the secondary reconstruction of a deficient sulcus. Most of these are associated with a variable ...
Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: a combined approach of structure-based virtual screening ADMET prediction and molecular dynamics simulation assay
(Taylor & Francis Inc, 2018)
Histone deacetylases (HDACs) have gained increased attention as targets for anticancer drug design and development. HDAC inhibitors have proven to be effective for reversing the malignant phenotype in HDAC-dependent cancer ...
Ligand-binding affinity of alternative conformers of human beta(2)-adrenergic receptor in the presence of intracellular loop 3 (ICL3) and their potential use in virtual screening studies
(Wiley, 2019)
This study investigates the structural distinctiveness of orthosteric ligand-binding sites of several human beta(2) adrenergic receptor (beta(2)-AR) conformations that have been obtained from a set of independent molecular ...
Psychosocial interventions to improve outcomes among dialysis patients
(Wiley, 2018)
Patients with end-stage renal disease (ESRD) report high levels of emotional problems and poor compliance with treatment and quality of life. Nevertheless there are not many studies which examine the effectiveness of ...
Factors that influence attitude and enforcement of the smoke-free law in Turkey: a survey of hospitality venue owners and employees
(Bmj Publishing Group, 2017)
Introduction In 2009 Turkey extended the smoke-free legislation to hospitality venues. Compliance however remains low in some hospitality venues. We identified characteristics associated with knowledge of health effects ...
Machine Learning Approaches for Predicting Protein Complex Similarity
(Mary Ann Liebert Inc Publ, 2017)
Discriminating native-like structures from false positives with high accuracy is one of the biggest challenges in protein-protein docking. While there is an agreement on the existence of a relationship between various ...
Synthesis anticancer activity and molecular modeling of etodolac-thioether derivatives as potent methionine aminopeptidase (type II) inhibitors
(Wiley, 2018)
A series of (RS)-1-{[5-(substituted)sulfanyl-4-substituted-4H-124-triazole-3-yl]methyl}-18-diethyl-1349-tetrahydropyrano[34-b]indoles (5a-v) were designed and synthesized using a five-step synthetic protocol that involves ...
The stability constants of the rare earth complexes with trimetaphosphoric acid
(Soc Chimica Italiana, 2001)
The stability constants of the complexes formed between the rare earth metal ions and the anion of trimetaphosphoric acid have been determined at a temperature of 20 degreesC and an ionic strength of mu =0.1 by the ...
Removal of UroLume endoprosthesis using holmium : YAG laser
(Mary Ann Liebert Inc Publ, 2001)
A potential complication of UroLume endoprosthesis is migration which may necessitate removal of the stent. Stent removal may be associated with complications such as urethral injury bleeding and external sphincter trauma. ...