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Design, Synthesis and In Vitro Cytotoxic Activity of New 6,9-Disubstituted Purine Analogues
(Slovensko Kemijsko Drustvo, 2020)
A series of new 6,9-disubstituted purine analogs with 4-substituted piperazine at C-6 and 4-substituted benzyl at N-9 were designed and synthesized in four steps. All synthesized compounds (7-26) were screened initially ...
The design of potent HIV-1 integrase inhibitors by a combined approach of structure-based virtual screening and molecular dynamics simulation
(Taylor & Francis Ltd, 2018)
Bu araştırmanın amacı, AIDS olarak bilinen insan bağışıklık sistemine etki eden, duraksamayan ve depresif bir hastalığa neden olan HIV-1'in tedavisi için potansiyel inhibitörleri elde etmektir. HIV-1 integraz inhibitörleri, ...
Lipoprotein lipase gene polymorphism and lipid profile in coronary artery disease
(COLL AMER PATHOLOGISTS, 2004)
Context.-Lipoprotein lipase (LPL) plays a central role in lipid metabolism hydrolyzing triglyceride in chylomicrons and very-low-density lipoproteins. The PvuII polymorphic variant of LPL gene is common and might affect ...
The protective effect of vitamin C vitamin E and selenium combination therapy on ethanol-induced duodenal mucosal injury
(Arnold Hodder Headline Plc., 2004)
In this study the effect of a combination of vitamin C vitamin E and selenium on ethanol-induced duodenal mucosal damage in rats was investigated morphologically and biochemically. The duodenal mucosal injury was produced ...
Pyoderma gangrenosum at the incision site following gynecologic surgery
(ELSEVIER SCI IRELAND LTD, 2004)
[Abstract Not Available]
Myositis ossificans of psoas muscle: Magnetic resonance imaging findings
(Blackwell Munksgaard, 2004)
Myositis ossificans is a benign localized self-limiting ossifying soft tissue mass with unknown pathogenesis. It may be confused with a malignant tumor of bone or soft tissues especially in the early stages of the disease. ...
Effects of vanadyl sulfate on liver of streptozotocin-induced diabetic rats
(Humana Press Inc., 2005)
The aim of this study was to investigate the microscopic and biochemical effects of vanadyl sulfate on liver tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a ...
Protective effects of a calcium channel blocker on apoptosis in thymus of neonatal STZ-diabetic rats
(Elsevier GMBH Urban & Fischer Verlag, 2005)
Streptozotocin (STZ) is known to induce insulin-dependent diabetes in experimental animals. In STZ-induced diabetes atrophy of the thymus is caused by elevated intracellular calcium levels leading to apoptosis. Hyperglycemia ...
Recurrent cholangitis associated with biliary sludge and Phrygian cap anomaly diagnosed by magnetic resonance imaging and magnetic resonance cholangiopancreatography despite normal ultrasound and computed tomography
(Taylor & Francis, 2005)
A 31-year-old woman presented with a one and half years' history of intermittent right upper quadrant (RUQ) pain high fever and severely painful warm and reddish swollen skin lesions on the fingers. Acute attack resolution ...
Renal-related perinephric fluid collections: MRI findings
(Elsevier Science Inc, 2005)
We retrospectively reviewed MR studies on 10 patients with renal-related perinephric fluid collections who underwent MRI in three institutions between January 2001 and August 2004. All patients underwent MRI of the abdomen ...