PubMed İndeksli Yayınlar Koleksiyonu
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Browsing PubMed İndeksli Yayınlar Koleksiyonu by Author "Advertising"
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Article Citation - WoS: 8Citation - Scopus: 9Antifungal Screening and in Silico Mechanistic Studies of an In-House Azole Library(2019) Sarı, Suat; Özdemir, Serpil; Kart, Didem; Sabuncuoğlu, Suna; Doğan, İnci Selin; Özdemir, Zeynep; Bozbey, İrem; Gencel, Melis; Eşsiz, Şebnem; Reynisson, Jóhannes; Karakurt, Arzu; Saraç, Selma; Dalkara, Sevim; AdvertisingSystemic Candida infections pose a serious public health problem with high morbidity and mortality. C. albicans is the major pathogen identified in candidiasis; however, non-albicans Candida spp. with antifungal resistance are now more prevalent. Azoles are first-choice antifungal drugs for candidiasis; however, they are ineffective for certain infections caused by the resistant strains. Azoles block ergosterol synthesis by inhibiting fungal CYP51, which leads to disruption of fungal membrane permeability. In this study, we screened for antifungal activity of an in-house azole library of 65 compounds to identify hit matter followed by a molecular modeling study for their CYP51 inhibition mechanism. Antifungal susceptibility tests against standard Candida spp. including C. albicans revealed derivatives 12 and 13 as highly active. Furthermore, they showed potent antibiofilm activity as well as neglectable cytotoxicity in a mouse fibroblast assay. According to molecular docking studies, 12 and 13 have the necessary binding characteristics for effective inhibition of CYP51. Finally, molecular dynamics simulations of the C. albicans CYP51 (CACYP51) homology model's catalytic site complexed with 13 were stable demonstrating excellent binding.Editorial Citation - WoS: 9Citation - Scopus: 9Beyond Sightseeing: How Can Tourism Affect Public/Global Health in Modern Society?(Int Soc Global Health, 2022) Wen, Jun; Kozak, Metin; Kozak, Metin; Jiang, Yangyang; Advertising[Abstract Not Available]Article Citation - Scopus: 9Beyond Sightseeing: How Can Tourism Affect Public/Global Health in Modern Society?(University of Edinburgh, 2022) Wen,J.; Kozak, Metin; Kozak,M.; Jiang,Y.; Advertising[No abstract available]Article Citation - WoS: 18Citation - Scopus: 18Impacts of Covid-19 on Changing Patterns of Household Food Consumption: an Intercultural Study of Three Countries(Elsevier, 2021) Kartari, Asker; Kartarı, Asker; Ozen, Asli Emine; Kozak, Metin; Correia, Antonia; Wen, Jun; Kozak, Metin; AdvertisingIn light of COVID-19's effects on individuals' social, economic, political, and psychological values, this paper aims to investigate the pandemic's role in possible changes to people's food consumption and meal habits in three countries, namely China, Portugal, and Turkey. The sample includes individuals from the three countries, exploratory factor analysis and non-parametric tests were used to test the differences. Results suggest that coronavirus has played a strong part in altering households' food consumption and meal habits within these countries. The pandemic has particularly led to greater consumption of fresh fruits and vegetables and spending more time eating meals at home. Portugal appears to be consuming more seafood, bread, and butter whereas China features higher consumption of rice and meat products; Turkey is consuming more meat and eggs. The study closes with a set of recommendations for the society and future research.Article Citation - WoS: 4Parental Use of Causal Language for Preterm and Full-Term Children: a Longitudinal Study(Cambridge Univ Press, 2023) Ozdemir, Salih C.; Özdemir, Serpil; Aktan-Erciyes, Asli; Goksun, Tilbe; AdvertisingParents are often a good source of information, introducing children to how the world around them is described and explained in terms of cause-and-effect relations. Parents also vary in their speech, and these variations can predict children's later language skills. Being born preterm might be related to such parent-child interactions. The present longitudinal study investigated parental causal language use in Turkish, a language with particular causative morphology, across three time points when preterm and full-term children were 14-, 20-, and 26-months-old. In general, although preterm children heard fewer words overall, there were no differences between preterm and full-term groups in terms of the proportion of causal language input. Parental causal language input increased from 20 to 26 months, while the amount of overall verbal input remained the same. These findings suggest that neonatal status can influence the amount of overall parental talk, but not parental use of causal language.Article Citation - WoS: 4Citation - Scopus: 4Positive Effects of Covid-19 on Food Preparation and Expenditure Habits: a Comparative Study Across Three Countries(Cambridge Univ Press, 2022) ozen, Asli Emine; Kartarı, Asker; Kartari, Asker; Kozak, Metin; Correia, Antonia; Wen, Jun; Kozak, Metin; AdvertisingObjective: This study seeks to empirically investigate how the changing eating habits affect health habits within three countries with entirely different cultures and diets to understand to what extent the pandemic may be responsible for these changes. Design: Specifically, a questionnaire was conducted in China, Portugal and Turkey in early 2021. A series of statistical analyses were performed to identify how changes in individuals' eating habits have influenced their diets, considering the pandemic context and the varying cultural contexts where this research was performed. Setting: A structured questionnaire form was developed and uploaded to an online platform with unique links for automatic distribution to respondents in each country. Data for the main survey were gathered between 3 January and 1 February 2021. Participants: Using snowball sampling, the authors leveraged their social networks by asking friends and colleagues to distribute the survey to potentially interested individuals. This distribution was stratified accordingly to the distribution of the population. The authors ultimately collected 319 useable surveys from China, 351 from Portugal and 449 from Turkey. Results: The pandemic inspired healthier food habits, mostly because people have additional time to cook, shop differently for food and spend more money on groceries. Conclusions: The study suggests that aside from cultural values and dietary habits, the available time and the fear of the pandemic most explained the new eating habits. Several implications are provided for researchers and overall society in these three countries.Editorial Citation - WoS: 4Citation - Scopus: 4Solidarity Tourism: a Pathway To Revitalising the Health of Vulnerable War-Affected Populations?(Int Soc Global Health, 2023) Wen, Jun; Kozak, Metin; Hu, Fangli; Zheng, Danni; Phau, Ian; Kozak, Metin; Hou, Haifeng; Wang, Wei; Advertising[Abstract Not Available]Article Citation - Scopus: 4Solidarity Tourism: a Pathway To Revitalising the Health of Vulnerable War-Affected Populations?(University of Edinburgh, 2023) Wen,J.; Kozak, Metin; Hu,F.; Zheng,D.; Phau,I.; Kozak,M.; Hou,H.; Wang,W.; Advertising[No abstract available]
