Browsing by Author "Ali, Mohsin"

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Citation Count: 18
Biodegradable Piezoelectric Polymers: Recent Advancements in Materials and Applications
(Wiley, 2023) Istıf, Emın; Bathaei, Mohammad Javad; Istif, Emin; Karimi, Seyed Nasir Hosseini; Beker, Levent
Recent materials, microfabrication, and biotechnology improvements have introduced numerous exciting bioelectronic devices based on piezoelectric materials. There is an intriguing evolution from conventional unrecyclable materials to biodegradable, green, and biocompatible functional materials. As a fundamental electromechanical coupling material in numerous applications, novel piezoelectric materials with a feature of degradability and desired electrical and mechanical properties are being developed for future wearable and implantable bioelectronics. These bioelectronics can be easily integrated with biological systems for applications, including sensing physiological signals, diagnosing medical problems, opening the blood-brain barrier, and stimulating healing or tissue growth. Therefore, the generation of piezoelectricity from natural and synthetic bioresorbable polymers has drawn great attention in the research field. Herein, the significant and recent advancements in biodegradable piezoelectric materials, including natural and synthetic polymers, their principles, advanced applications, and challenges for medical uses, are reviewed thoroughly. The degradation methods of these piezoelectric materials through in vitro and in vivo studies are also investigated. These improvements in biodegradable piezoelectric materials and microsystems could enable new applications in the biomedical field. In the end, potential research opportunities regarding the practical applications are pointed out that might be significant for new materials research.
Citation Count: 0
Investigation of dynamic micromechanical properties of biodegradable elastic material by continuous stiffness measurement analysis
(Sage Publications Ltd, 2023) Istıf, Emın; Istif, Emin; Bathaei, Mohammad Javad; Beker, Levent
Micromechanical properties of polymeric materials play a critical role in various biological applications in terms of their biocompatibility and mechanical durability. Apart from material properties such as modulus and density, viscoelastic properties play a crucial role during the design and fabrication of devices. Here, we investigated the viscoelastic properties of poly (glycerol sebacate) (PGS), a widely used bioresorbable elastic material, through the nanoindentation technique, configured by the continuous stiffness measurement (CSM) method at frequencies from 10 Hz to 50 Hz. The results revealed that the storage modulus (E') depends on the test frequency and cannot be ignored as the results showed significant changes. Additionally, increasing the curing temperature of PGS specimens between 150 to 170 & DEG;C allows modifying the storage modulus of samples between 0.52 MPa and 1.05 MPa at 10 Hz. The results were also confirmed using the dynamic mechanical measurements to validate the reliability of the CSM nanoindentation technique.
Citation Count: 0
Near-Infrared Triggered Degradation for Transient Electronics
(Amer Chemical Soc, 2024) Istıf, Emın; Ali, Mohsin; Ozuaciksoz, Elif Yaren; Morova, Yagiz; Beker, Levent
Electronics that disintegrate after stable operation present exciting opportunities for niche medical implant and consumer electronics applications. The disintegration of these devices can be initiated due to their medium conditions or triggered by external stimuli, which enables on-demand transition. An external stimulation method that can penetrate deep inside the body could revolutionize the use of transient electronics as implantable medical devices (IMDs), eliminating the need for secondary surgery to remove the IMDs. We report near-infrared (NIR) light-triggered transition of metastable cyclic poly-(phthalaldehyde) (cPPA) polymers. The transition of the encapsulation layer is achieved through the conversion of NIR light to heat, facilitated by bioresorbable metals, such as molybdenum (Mo). We reported a rapid degradation of cPPA encapsulation layer about 1 min, and the rate of degradation can be controlled by laser power and exposure time. This study offers a new approach for light triggerable transient electronics for IMDs due to the deep penetration depth of NIR light through to organs and tissues.