Browsing by Author "Cakali, Emine"

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Citation Count: 0
Diltiazemin internal torasik arter kan akımı üzerine etkisi
(1996) Akpinar, Belhhan; Çetin, Gürkan; Bayındır, Osman; Cakali, Emine; Pekcan, Ülkü; Sönmez, Bingür
Bir kalsiyum antagonist! olan diltiazemin koroner arter cerrahisinde internal torasik arter (İTA) akımı üzerindeki etkisini incelemek üzere 60 olgu üzerinde yapılan çalışmada, 30 olguya peroperatif 0.1 mg/kg/saat - 0.3 mg /kg / saat arasında değişen dozlarda diltiazem perfüzyonu başlandı ve 24 saat devam edildi (Grup 1). Diğer 30 olguya (Grup 2) diltiazem verilmedi. Yapılan ölçümlerde İTA kan akımı Grup Vde 110 ± 5 ml/dk, Grup 2'de 70 ± 7 mi/ dk bulundu (p < 0.05). Grup 2'deki olgulara İTA içine papaverin enjekte edildikten sonra yapılan ölçümlerde İTA kan akımı 120 ± 5 mi olarak ölçüldü. Elde edilen gözlem, peroperatif başlanan diltiazem perfüzyonunun İTA kan akımını önemli ölçüde artırdığı şeklindedir.
Citation Count: 18
Does normoxemic cardiopulmonary bypass prevent myocardial reoxygenation injury in cyanotic children?
(W.B. Saunders Co Ltd, 2002) Bulutcu, Füsun S.; Bayındır, Osman; Polat, Bülent; Yalçın, Yalim; Özbek, Uğur; Cakali, Emine
Objective: To evaluate whether the deleterious effect of cardiopulmonary bypass (CPB) can be prevented by controlling PaO2 in cyanotic children. Design: Prospective randomized clinical study. Setting: Single university hospital. Participants: Pediatric patients undergoing cardiac surgery for repair of congenital heart disease (n = 24). Interventions: Patients were randomly allocated into 3 groups. Patients in the acyanotic group (group I n = 10) had CPB initiated at a fraction of inspired oxygen (F1O2) of 1.0 (PO2 300 to 350 mmHg). Cyanotic patients were subdivided as follows: Group 11 (n = 7) had CPB initiated at an F1O2 of 1.0 and group III (n = 7) had CPB initiated at an F1O2 of 0.21 (PO2 90 to 110 mmHg). A biopsy specimen of right atrial tissue was removed during venous cannulation and another sample was removed after CPB before aortic cross-clamping. The tissue was incubated in 4 mmol/L of t-butylhydroperoxide and the malondialdehyde (MDA) level was measured to determine the antioxidant reserve capacity. Blood samples for cytokine levels tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 response to CPB were collected after induction of anesthesia and at the end of CPB before prolamine administration. Measurements and Main Results: After initiation of CPB MDA level rose markedly in the cyanotic groups compared with the acyanotic group (210 +/- 118% v 52 +/- 34% p < 0.05) which indicated the depletion of antioxidants. After initiation of CPB TNF-&alpha
Citation Count: 25
Effects of intravenous triiodothyronine during coronary artery bypass surgery
(Asia Publishing Exchange Pte Ltd, 2002) Güden, Mustafa; Akpınar, Belhhan; Sağbaş, Ertan; Sanisoğlu, İlhan; Cakali, Emine; Bayındır, Osman
A prospective randomized and double-blind study was performed to evaluate whether perioperative triiodothyronine administration has any effect on cardiovascular performance after coronary artery bypass surgery. Sixty patients were assigned to 2 groups of 30 each. When crossclamping ended group A received an intravenous bolus of triiodothyronine followed by infusion for 6 hours. Group B received a placebo. Serum triiodothyronine levels and hemodynamic parameters were serially measured. Mean postoperative cardiac index was slightly but not significantly higher in group A whereas systemic vascular resistance was significantly lower in group A. Compared with preoperative values serum triiodothyronine levels dropped significantly in group B at the end of cardiopulmonary bypass and remained low 12 hours postoperatively while levels rose significantly in group A. No significant differences were detected between the groups in the incidence of arrhythmia the need for inotropic support intensive care unit stay mortality and morbidity. Perioperative administration of triiodothyronine increased cardiac output slightly and decreased systemic vascular resistance but it had no effect on operative outcome. Routine use after coronary surgery is thus not recommended.
Citation Count: 76
Which anesthetic agent alters the hemodynamic status during pediatric catheterization? Comparison of propofol versus ketamine
(W.B. Saunders Co Ltd, 2003) Oklu, E; Bulutcu, Füsun S.; Yalçın, Yalim; Özbek, Uğur; Cakali, Emine; Bayındır, Osman
Objective: To compare the effects of propofol and ketamine on systemic and pulmonary circulations in pediatric patients scheduled for elective cardiac catheterization. Design: Prospective randomized and blinded. Setting: University hospital. Participants: Children (n = 41) undergoing cardiac catheterization. Interventions: All children were premedicated with oral midazolam 60 minutes before the procedure. Patients were separated into 3 groups according to shunts diagnosed by transthoracic echocardiography before the catheterization procedure: patients without cardiac shunt (Group 1 n = 11) left-to-right shunt (Group 11 n = 12) and right-to-left shunt (Group III n = 18). A continuous infusion of propofol (100200 mug/kg/min) or ketamine (50-75 mug/kg/min) was randomly started in all groups to obtain immobility during the procedure. Hemodynamic data including systemic venous pulmonary artery and vein aortic saturations and pressures were recorded