Browsing by Author "Isgor, Pelin Kubra"

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    Paper Integrated Microfluidic Contact Lens for Colorimetric Glucose Detection
    (Royal Soc Chemistry, 2024) Isgor, Pelin Kubra; Abbasiasl, Taher; Das, Ritu; Istif, Emin; Yener, Umut Can; Beker, Levent
    Contact lenses offer a simple, cost-effective, and non-invasive method for in situ real-time analysis of various biomarkers. Electro-chemical sensors are integrated into contact lenses for analysis of various biomarkers. However, they suffer from rigid electronic components and connections, leading to eye irritation and biomarker concentration deviation. Here, a flexible and microfluidic integrated paper-based contact lens for colorimetric analysis of glucose was implemented. Facilitating a three-dimensional (3D) printer for lens fabrication eliminates cumbersome cleanroom processes and provides a simple, batch compatible process. Due to the capillary force of the filter paper, the sample was routed to detection chambers inside microchannels, and it allowed further colorimetric detection. The paper-embedded microfluidic contact lens successfully detects glucose down to 2 mM within similar to 10 s. The small dimension of the microfluidic system enables detection of glucose levels as low as 5 mu l. The results show the potential of the presented approach to analyze glucose concentration in a rapid manner. It is demonstrated that the fabricated contact lens can successfully detect glucose levels of diabetic patients. Contact lenses offer a simple, cost-effective, and non-invasive method for in situ real-time analysis of various biomarkers.