Browsing by Author "Karakus, Selcan"

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Citation - WoS: 25
Citation - Scopus: 21
Design, characterization and evaluation of the drug-loaded chitosan/cerium oxide nanoparticles with pH-controlled drug release
(Springer, 2022) Ilgar, Merve; Karakus, Selcan; Kilislioglu, Ayben
In recent years, polymer/metal oxide nanoparticles as a high-performance nanomaterials have gained great attention in different industrial areas such as biotechnology, cosmetic, automotive, textile, and concrete. In this study, novel chitosan/cerium oxide nanoparticles (Chi/CeO2 NPs) were synthesized to improve the bioavailability of the drug based on the assembly of inorganic nanoparticles at the polymer-NPs interfaces. The surface morphological property, chemical structure and drug release profile of synthesized NPs were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectrophotometer (FTIR) X-ray diffractometer (XRD), and UV-visible technique. The particle size of spherical Chi/CeO2 NPs was found to be < 40 nm with a prepotent surface. Different kinetic model parameters such as zero-order, first-order, Higuchi, Bhaskar, and Ritger-Peppas models were calculated to investigate the drug release mechanism. The amount of Methotrexate (MTX) release from the surface of CeO2 NPs and the interface of Chi/CeO2 NPs were found to be 12.4% and 66.26%, respectively. According to experimental results, we observed that interfaces between Chi/CeO2 NPs and MTX in a structure could have a profound effect on the percentage of MTX drug release. We showed that the synthesized inorganic NPs could be proposed potentially as an effective inorganic nanocarrier with controlled MTX release.
Citation - WoS: 5
Citation - Scopus: 5
Improvement of mechanical strength of mortars by different morphological zinc oxide nanoparticles
(ICE Publishing, 2022) Yazgan, Ahmet Utku; Karakus, Selcan; Pehlivan, Ahmet Onur; Karapinar, Isil Sanri; Ozbay, Ayse Elif Ozsoy; Tasaltin, Nevin; Kilislioglu, Ayben
This study presents novel nano-mixtures containing zinc oxide (ZnO) nanoparticles (NPs) to enhance the mechanical properties of cement mortars. Different morphological ZnO NPs were synthesised through the green sonochemical method, using tragacanth gum/Kappa carrageenan (TG/kappa-C) and tragacanth gum/chitosan (TG/CS) as biopolymer matrices. The ZnO NPs were characterised using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, X-ray diffraction, Zetasizer and Brunauer-Emmett-Teller techniques. The intrinsic viscosities of TG/kappa-C-ZnO and TG/CS-ZnO NPs were investigated to determine the miscibility of the polymeric blends in aqueous solution as affected by sonication time and composition ratios. The average diameters for the spherical and prism-like ZnO NPs were around 266 nm and 355 nm, respectively. Seven different cement mortar specimens containing TG/kappa-C-ZnO and TG/CS-ZnO NPs were prepared in ratios of 0, 0.1, 0.5 and 1% by weight, and the flexural and compressive strengths of the specimens were determined at the ages of 7 and 28 days. The results indicate that there is a significant improvement in the mechanical performance of different morphological ZnO NP-based cement mortar composites. In comparison, it was observed that specimens containing TG/kappa-C-ZnO NPs had much better results than TG/CS-ZnO NPs. Moreover, the workability problem encountered by using only ZnO NPs has been overcome with the presented biopolymers used in this study.
Citation - WoS: 9
Citation - Scopus: 11
The In-Vivo Assessment of Turkish Propolis and Its Nano Form on Testicular Damage Induced by Cisplatin
(Elsevier, 2021) Seven, Pinar Tatli; Seven, Ismail; Karakus, Selcan; Mutlu, Seda Iflazoglu; Kaya, Seyma Ozer; Arkali, Gozde; Ilgar, Merve
Objective: Chemotherapeutic drugs, such as cisplatin (CP), which are associated with oxidative stress and apoptosis, may adversely affect the reproductive system. This study tests whether administration of propolis and nano-propolis (NP) can alleviate oxidative stress and apoptosis in rats with testicular damage induced by CP. Methods: In this study, polymeric nanoparticles including propolis were synthesized with a green sonication method and characterized using Fourier transform-infrared spectroscopy, Brunauer-EmmettTeller, and wet scanning transmission electron microscopy techniques. In total, 56 rats were divided into the following seven groups: control, CP, propolis, NP-10, CP + propolis, CP + NP-10, and CP + NP-30. Propolis (100 mg/kg), NP-10 (10 mg/kg), and NP-30 (30 mg/kg) treatments were administered by gavage daily for 21 d, and CP (3 mg/kg) was administered intraperitoneally in a single dose. After the experiment, oxidative stress parameters, namely, malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT), and apoptotic pathways including B cell leukemia/lymphoma-2 protein (Bcl-2) and Bcl-2-associated X protein (Bax) were measured in testicular tissues. Furthermore, sperm quality and weights of the testis, epididymis, right cauda epididymis, seminal vesicles and prostate were evaluated. Results: Propolis and NP (especially NP-30) were able to preserve oxidative balance (decreased MDA levels and increased GSH, CAT, and GPx activities) and activate apoptotic pathways (decreased Bax and increased Bcl-2) in the testes of CP-treated rats. Sperm motility in the control, CP, and CP + NP-30 groups were 60%, 48.75%, and 78%, respectively (P < 0.001). Especially, NP-30 application completely corrected the deterioration in sperm features induced by CP. Conclusion: The results show that propolis and NP treatments mitigated the side effects of CP on spermatogenic activity, antioxidant situation, and apoptosis in rats. (C) 2021 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by ELSEVIER B.V. All rights reserved.
Investigation of the Mechanical Strength of Cement Mortars Containing Novel Synthesised Chitosan/Hydromagnesite Stromatolite Nano-Composite
(Croatian Soc Civil Engineers-Hsgi, 2025) Karakus, Selcan; Ozbay, Ayse Elif Ozsoy; Pehlivan, Ahmet Onur; Yazgan, Ahmet Utku; Karapinar, Isil Sanri; Tasaltin, Nevin; Kilislioglu, Ayben
This study introduces the use of a novel synthesised chitosan/hydromagnesite stromatolite (CHT/HS) nano-composite in cement mortars and investigates its effects on the mechanical properties. The proposed bio-based nano-composite was synthesised by a green sonication method using HS originating from Salda Lake (Burdur, Turkey). The chemical and morphological properties of HS and CHT/HS nano-composites were determined. Specimens including HS in ratios of 5 and 10 % and CHT/HS nanostructures with 0.1, 0.5, 1 and 2 % were tested for flexural and compressive strengths for 7 and 28 days. The novel synthesised CHT/HS nano-composite showed a clear enhancement in mechanical strength. These findings suggest directions for future work on different nano-filler applications.
Citation - WoS: 1
Citation - Scopus: 1
Mechanical Properties of Cement Mortars Incorporating Zero-Valent Iron Nanoparticles
(Asce-Amer Soc Civil Engineers, 2022) Ozbay, Ayse Elif Ozsoy; Karapinar, Isil Sanri; Yazgan, Ahmet Utku; Pehlivan, Ahmet Onur; Karakus, Selcan; Tasaltin, Nevin; Kilislioglu, Ayben
In this study, the effects of zero-valent iron (ZVI) nanoparticles (NPs) on the mechanical performance of cementitious composites were investigated. For this purpose, the use of a novel nanomaterial containing ZVI NPs blended with carboxymethyl cellulose (CMC) and SiO2 was introduced. CMC/SiO2-ZVI NPs were prepared by a green and low-cost sonochemical method at room temperature and characterized using scanning electron microscopy/energy dispersive X-ray spectroscopy, thermal gravimetry analysis, Brunauer-Emmett-Teller, and X-ray diffraction techniques. The values of intrinsic viscosities of CMC/SiO2-ZVI NPs were examined to determine the optimal miscible condition as affected by the different mass ratios of CMC/SiO2 and sonication time. Then, eight different cement mortar specimens containing CMC/SiO2 and CMC/SiO2-ZVI NPs were prepared in ratios of 0.2%, 0.5%, 1%, and 2% by weight, and flexural and compressive strengths of the specimens were determined at the ages of 7 and 28 days. The microstructure of the specimens was also evaluated. Comprehensive results proving the improvement in the mechanical properties have been obtained in the specimens containing 1% and 2% CMC/SiO2-ZVI NPs. (C) 2021 American Society of Civil Engineers.