PubMed İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12469/4466
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Article Citation - WoS: 79Citation - Scopus: 95The association of the severity of obstructive sleep apnea with plasma leptin levels(Amer Medical Assoc., 2003) Öztürk, Levent; Ünal, Murat; Tamer, Lülüfer; Çelikoğlu, FiruzObjective: To examine whether circulating leptin levels correlate with the severity of disease in patients with obstructive sleep apnea. Design: Prospective nonrandomized study. Setting: Referral sleep laboratory for patients with sleep-disordered breathing and biochemistry laboratory. Patients: Thirty-two subjects (mean+/-SD age 47+/-12 years) who were referred for suspected sleep apnea underwent an overnight sleep study and fasting morning venous blood sampling. Patients were divided into 3 groups with respect to apnea-hypopnea index: (1) severe sleep apnea (n=8) apnea-hypopnea index greater than 20Article Citation - WoS: 108Citation - Scopus: 127Cognitive impairment in amyotrophic lateral sclerosis: evidence from neuropsychological investigation and event-related potentials(Elsevier Science Bv, 2002) Hanagasi, Hasmet A.; Gurvit, I. Hakan; Ermutlu, Numan; Kaptanoğlu, Gulustu; Karamürsel, Sacit; Idrisoğlu, Halil A.; Emre, Murat; Demiralp, TamerThe presence of subclinical cognitive impairment in patients with amyotrophic lateral sclerosis (ALS) is investigated using neuropsychological assessment and event-related potential recordings (ERP). An extensive battery of neuropsychological tests assessing the domains of attention memory language visuo-spatial and executive functions were administered to 20 non-demented patients with sporadic ALS and 13 age- and education-matched healthy control subjects. Mismatch negativity (MMN) P3b P3a (novelty P300) and contingent negative variation (CNV) were recorded. ALS patients were significantly impaired in tests of working memory sustained attention response inhibition naming verbal fluency and complex visuo-spatial processing. The memory impairment seemed to be secondary to deficits in forming learning strategies and retrieval. In ERP recordings P3a and P3b amplitudes of ALS patients were lower compared with the controls P3a latencies were significantly longer and mean CNV amplitudes were higher. These results indicate subclinical impairment of cognitive functions in patients with ALS. The pattern of cognitive impairment suggests the dysfunction of the frontal network. (C) 2002 Elsevier Science B.V. All rights reserved.Letter Citation - Scopus: 1The fragile point of cardiac rehabilitation: Exercise compliance (The effects of phase II cardiac rehabilitation programme on patients undergone coronary bypass surgery) (multiple letters)(2005) Kaşikcioğlu, E.; Çiftci, Ç.[No abstract available]Book Part Hands-On Docking With Molegro Virtual Docker(Humana Press Inc., 2026) Dere, D.; Pehlivan, S.N.; da Silva, A.D.; de Azevedo Junior, W.F.Molegro Virtual Docker (MVD) integrates state-of-the-art search algorithms and scoring functions dedicated to protein-ligand docking simulations. It implements differential evolution as a search engine and MolDock and Plants scores to calculate binding affinity. In this work, we describe a workflow focused on how to build regression models to predict the inhibition of cyclin-dependent kinase 2 (CDK2). We employ available structural and binding data to construct machine learning models to calculate CDK2 inhibition based on the atomic coordinates obtained through docking simulations performed with MVD. We present a hands-on approach to show how to integrate docking results and machine learning methods available at Scikit-Learn to build targeted scoring functions. Our regression models show superior predictive performance compared with classical scoring functions. All CDK2 datasets and Jupyter Notebooks discussed in this work are available at GitHub: https://github.com/azevedolab/docking#readme. We made the source code of the program SAnDReS 2.0 available at https://github.com/azevedolab/sandres. © 2025 Elsevier B.V., All rights reserved.
