PubMed İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12469/4466

Browse

Now showing 1 - 20 of 206

Citation - WoS: 15
Citation - Scopus: 15
2d Materials (ws2, Mos2, Mose2) Enhanced Polyacrylamide Gels for Multifunctional Applications
(Mdpi, 2022) Uysal, Bengu Ozugur; Nayir, Seyma; Acba, Melike; Citir, Betul; Durmaz, Sumeyye; Kocoglu, Sevval; Yildiz, Ekrem
Multifunctional polymer composite gels have attracted attention because of their high thermal stability, conductivity, mechanical properties, and fast optical response. To enable the simultaneous incorporation of all these different functions into composite gels, the best doping material alternatives are two-dimensional (2D) materials, especially transition metal dichalcogenides (TMD), which have been used in so many applications recently, such as energy storage units, opto-electronic devices and catalysis. They have the capacity to regulate optical, electronic and mechanical properties of basic molecular hydrogels when incorporated into them. In this study, 2D materials (WS2, MoS2 and MoSe2)-doped polyacrylamide (PAAm) gels were prepared via the free radical crosslinking copolymerization technique at room temperature. The gelation process and amount of the gels were investigated depending on the optical properties and band gap energies. Band gap energies of composite gels containing different amounts of TMD were calculated and found to be in the range of 2.48-2.84 eV, which is the characteristic band gap energy range of promising semiconductors. Our results revealed that the microgel growth mechanism and gel point of PAAm composite incorporated with 2D materials can be significantly tailored by the amount of 2D materials. Furthermore, tunable band gap energies of these composite gels are crucial for many applications such as biosensors, cartilage repair, drug delivery, tissue regeneration, wound dressing. Therefore, our study will contribute to the understanding of the correlation between the optical and electronic properties of such composite gels and will help to increase the usage areas so as to obtain multifunctional composite gels.
Citation - WoS: 22
Citation - Scopus: 25
Absolute Configuration and Biological Profile of Pyrazoline Enantiomers as Mao Inhibitory Activity
(Wiley, 2019) Goksen, Umut Salgin; Sarıgül, Sevgi; Bultinck, Patrick; Herrebout, Wouter; Doğan, İlknur; Yelekçi, Kemal; Uçar, Gülberk; Kelekçi, Nesrin Gökhan
A new racemic pyrazoline derivative was synthesized and resolved to its enantiomers using analytic and semipreparative high-pressure liquid chromatography. The absolute configuration of both fractions was established using vibrational circular dichroism. The in vitro monoamine oxidase (MAO) inhibitory profiles were evaluated for the racemate and both enantiomers separately for the two isoforms of the enzyme. The racemic compound and both enantiomers were found to inhibit hMAO-A selectively and competitively. In particular the R enantiomer was detected as an exceptionally potent and a selective MAO-A inhibitor (K-i = 0.85 x 10(-3) +/- 0.05 x 10(-3) mu M and SI: 2.35 x 10(-5)) whereas S was determined as poorer compound than R in terms of K-i and SI (0.184 +/- 0.007 and 0.001). The selectivity of the enantiomers was explained by molecular modeling docking studies based on the PDB enzymatic models of MAO isoforms.
Citation - WoS: 7
Citation - Scopus: 6
The acquisition and use of relative clauses in Turkish-learning children's conversational interactions: a cross-linguistic approach
(Cambridge University Press, 2019) Uzundağ, Berna A.; Küntay, Aylin C.
Using a cross-linguistic approach, we investigated Turkish-speaking children's acquisition and use of relative clauses (RCs) by examining longitudinal child-caregiver interactions and cross-sectional peer conversations. Longitudinal data were collected from 8 children between the ages of 8 and 36 months. Peer conversational corpus came from 78 children aged between 43 and 64 months. Children produced RCs later than in English (Diessel, 2004) and Mandarin (Chen & Shirai, 2015), and demonstrated increasing semantic and structural complexity with age. Despite the morphosyntactic difficulty of object RCs, and prior experimental findings showing a subject RC advantage, preschool-aged children produced object RCs, which were highly frequent in child-directed speech, as frequently as subject RCs. Object RCs in spontaneous speech were semantically less demanding (with pronominal subjects and inanimate head nouns) than the stimuli used in prior experiments. Results suggest that multiple factors such as input frequency and morphosyntactic and semantic difficulty affect the acquisition patterns.
The Acquisition and Use of Relative Clauses in Turkish-Learning Children's Conversational Interactions: a Cross-Linguistic Approach (vol 46, Pg 1142, 2019)
(Cambridge Univ Press, 2022) Uzundag, Berna A.; Kuntay, Aylin C.
[Abstract Not Available]
Citation - WoS: 1
Citation - Scopus: 1
Across Dimensions: Two- and Three-Dimensional Phase Transitions From the Iterative Renormalization-Group Theory of Chains
(2020) Keçoğlu, İbrahim; Berker, A. Nihat
Sharp two- and three-dimensional phase transitional magnetization curves are obtained by an iterative renormalization-group coupling of Ising chains, which are solved exactly. The chains by themselves do not have a phase transition or nonzero magnetization, but the method reflects crossover from temperaturelike to fieldlike renormalization-group flows as the mechanism for the higher-dimensional phase transitions. The magnetization of each chain acts, via the interaction constant, as a magnetic field on its neighboring chains, thus entering its renormalization-group calculation. The method is highly flexible for wide application.
Citation - WoS: 138
Citation - Scopus: 139
Addressing Climate Change With Behavioral Science: a Global Intervention Tournament in 63 Countries
(Amer Assoc Advancement Science, 2024) Vlasceanu, Madalina; Doell, Kimberly C.; Bak-Coleman, Joseph B.; Todorova, Boryana; Berkebile-Weinberg, Michael M.; Grayson, Samantha J.; Van Bavel, Jay J.
Effectively reducing climate change requires marked, global behavior change. However, it is unclear which strategies are most likely to motivate people to change their climate beliefs and behaviors. Here, we tested 11 expert-crowdsourced interventions on four climate mitigation outcomes: beliefs, policy support, information sharing intention, and an effortful tree-planting behavioral task. Across 59,440 participants from 63 countries, the interventions' effectiveness was small, largely limited to nonclimate skeptics, and differed across outcomes: Beliefs were strengthened mostly by decreasing psychological distance (by 2.3%), policy support by writing a letter to a future-generation member (2.6%), information sharing by negative emotion induction (12.1%), and no intervention increased the more effortful behavior-several interventions even reduced tree planting. Last, the effects of each intervention differed depending on people's initial climate beliefs. These findings suggest that the impact of behavioral climate interventions varies across audiences and target behaviors.
Citation - WoS: 21
Citation - Scopus: 31
Adoption of Mobile Health Apps in Dietetic Practice: Case Study of Diyetkolik
(Jmır Publıcatıons, Inc, 130 Queens Quay E, 2020) Akdur, Görkem; Aydın, Mehmet Nafiz; Akdur, Gizdem
Background: Dietetics mobile health apps provide lifestyle tracking and support on demand. Mobile health has become a new trend for health service providers through which they have been shifting their services from clinical consultations to online apps. These apps usually offer basic features at no cost and charge a premium for advanced features. Although diet apps are now more common and have a larger user base, in general, there is a gap in literature addressing why users intend to use diet apps. We used Diyetkolik, Turkey's most widely used online dietetics platform for 7 years, as a case study to understand the behavioral intentions of users. Objective: The aim of this study was to investigate the factors that influence the behavioral intentions of users to adopt and use mobile health apps. We used the Technology Acceptance Model and extended it by exploring other factors such as price-value, perceived risk, and trust factors in order to assess the technology acceptance of users. Methods: We conducted quantitative research on the Diyetkolik app users by using random sampling. Valid data samples gathered from 658 app users were analyzed statistically by applying structural equation modeling. Results: Statistical findings suggested that perceived usefulness (P<.001), perceived ease of use (P<.001), trust (P<.001), and price-value (P<.001) had significant relationships with behavioral intention to use. However, no relationship between perceived risk and behavioral intention was found (P=.99). Additionally, there was no statistical significance for age (P=.09), gender (P=.98), or previous app use experience (P=.14) on the intention to use the app. Conclusions: This research is an invaluable addition to Technology Acceptance Model literature. The results indicated that 2 external factors (trust and price-value) in addition to Technology Acceptance Model factors showed statistical relevance with behavioral intention to use and improved our understanding of user acceptance of a mobile health app. The third external factor (perceived risk) did not show any statistical relevance regarding behavioral intention to use. Most users of the Diyetkolik dietetics app were hesitant in purchasing dietitian services online. Users should be frequently reassured about the security of the platform and the authenticity of the platform's dietitians to ensure that users' interactions with the dietitians are based on trust for the platform and the brand.
Analogy Is Indispensable but Rule Is a Must: Insights From Turkish
(Cambridge Univ Press, 2022) Nakipoglu, Mine; Uzundag, Berna A.; Ketrez, F. Nihan
Inflectional morphology provides a unique platform for a discussion of whether morphological productivity is rule-based or analogy-based. The present study testing 140 children (range = 29 to 97 months; M(SD) = 64.1(18.8)) on an elicited production task investigated the acquisition of the irregular distribution in the Turkish aorist. Results suggested that to discover the allomorphs of the Turkish aorist, children initially carried out similarity comparisons between analogous exemplars, which helped them tap into phonological features to induce generalizations for regulars and irregulars. Thereafter to tackle the irregularity, children entertained competing hypotheses yielding overregularizations and irregularizations. While the trajectory of overregularizations implicated the gradual formulation of an abstraction based on type-frequency, irregularizations suggested both intrusion of analogous exemplars and children's attempts to default to an erroneous micro-generalization. Our findings supported a model of morphological learning that is driven by analogy at the outset and that invokes rule-induction in later stages.
Citation - WoS: 2
Citation - Scopus: 2
Anomalous Pancreaticobiliary Junction (apbj) With the Drainage of the Uncinate Process Into the Minor Papilla: Demonstration by Mri
(BRITISH INST RADIOLOGY, 2005) Başaranoğlu, Metin; Balcı, Numan Cem; Kloer, Hans Ulrich
We report a case of a 30-year-old patient with anomalous pancreaticobiliary junction (APBJ) that has not been described before. The patient had a clinical history of recurrent attacks of pancreatitis cholangitis and cholecystitis that were confirmed by abnormal laboratory values. Endoscopic retrograde cholangiopancreatography revealed a 20 mm long junction of choledoc and pancreatic duct and uncinate process draining into the minor papilla. On MR cholangiopancreatography strictures at the junction of hepatic duct increased gallbladder wall thickness and intraductal stone in the pancreatic duct were demonstrated as complementary findings. Other MRI findings included decreased signal intensity of the pancreas consistent with fibrosis from past pancreatitis attacks and atrophy of the left liver lobe.
Citation - WoS: 101
Citation - Scopus: 172
The Applications of Machine Learning Techniques in Medical Data Processing Based on Distributed Computing and the Internet of Things
(Elsevier Ireland Ltd, 2023) Aminizadeh, Sarina; Heidari, Arash; Toumaj, Shiva; Darbandi, Mehdi; Navimipour, Nima Jafari; Rezaei, Mahsa; Talebi, Samira
Medical data processing has grown into a prominent topic in the latest decades with the primary goal of maintaining patient data via new information technologies, including the Internet of Things (IoT) and sensor technologies, which generate patient indexes in hospital data networks. Innovations like distributed computing, Machine Learning (ML), blockchain, chatbots, wearables, and pattern recognition can adequately enable the collection and processing of medical data for decision-making in the healthcare era. Particularly, to assist experts in the disease diagnostic process, distributed computing is beneficial by digesting huge volumes of data swiftly and producing personalized smart suggestions. On the other side, the current globe is confronting an outbreak of COVID-19, so an early diagnosis technique is crucial to lowering the fatality rate. ML systems are beneficial in aiding radiologists in examining the incredible amount of medical images. Nevertheless, they demand a huge quantity of training data that must be unified for processing. Hence, developing Deep Learning (DL) confronts multiple issues, such as conventional data collection, quality assurance, knowledge exchange, privacy preservation, administrative laws, and ethical considerations. In this research, we intend to convey an inclusive analysis of the most recent studies in distributed computing platform applications based on five categorized platforms, including cloud computing, edge, fog, IoT, and hybrid platforms. So, we evaluated 27 articles regarding the usage of the proposed framework, deployed methods, and applications, noting the advantages, drawbacks, and the applied dataset and screening the security mechanism and the presence of the Transfer Learning (TL) method. As a result, it was proved that most recent research (about 43%) used the IoT platform as the environment for the proposed architecture, and most of the studies (about 46%) were done in 2021. In addition, the most popular utilized DL algorithm was the Convolutional Neural Network (CNN), with a percentage of 19.4%. Hence, despite how technology changes, delivering appropriate therapy for patients is the primary aim of healthcare-associated departments. Therefore, further studies are recommended to develop more functional architectures based on DL and distributed environments and better evaluate the present healthcare data analysis models.
Citation - WoS: 5
Citation - Scopus: 5
Asymmetric Phase Diagrams, Algebraically Ordered Berezinskii-Kosterlitz Phase, and Peninsular Potts Flow Structure in Long-Range Spin Glasses
(Amer Physical Soc, 2022) Gurleyen, S. Efe; Berker, A. Nihat
The Ising spin-glass model on the three-dimensional (d = 3) hierarchical lattice with long-range ferromagnetic or spin-glass interactions is studied by the exact renormalization-group solution of the hierarchical lattice. The chaotic characteristics of the spin-glass phases are extracted in the form of our calculated, in this case continuously varying, Lyapunov exponents. Ferromagnetic long-range interactions break the usual symmetry of the spin-glass phase diagram. This phase-diagram symmetry breaking is dramatic, as it is underpinned by renormalization-group peninsular flows of the Potts multicritical type. A Berezinskii-Kosterlitz-Thouless (BKT) phase with algebraic order and a BKT-spin-glass phase transition with continuously varying critical exponents are seen. Similarly, for spin-glass long-range interactions, the Potts mechanism is also seen, by the mutual annihilation of stable and unstable fixed distributions causing the abrupt change of the phase diagram. On one side of this abrupt change, two distinct spin-glass phases, with finite (chaotic) and infinite (chaotic) coupling asymptotic behaviors are seen with a spin-glass to spin-glass phase transition.
Citation - Scopus: 2
Author Correction: National Identity Predicts Public Health Support During a Global Pandemic (nature Communications, (2022), 13, 1, (517), 10.1038/S41467-021-27668-9)
(Nature Research, 2022) Van, Bavel, J.J.; Cichocka, A.; Capraro, V.; Sjåstad, H.; Nezlek, J.B.; Pavlovi?, T.; Alfano, M.
In this article the author name ‘Agustin Ibanez’ was incorrectly written as ‘Augustin Ibanez’. The original article has been corrected. © The Author(s) 2022.
Citation - WoS: 5
Citation - Scopus: 5
The Availability of Emergency Contraception From Family Health Centers in Turkey
(Elsevier Ireland Ltd, 2022) O'Neil, Mary Lou; Aldanmaz, Bahar; Altuntas, Deniz
Reproductive health care, including contraception, is a fundamental aspect of any public health care system and it is important to reduce barriers to access to all forms of contraception, including emergency contraception. In recent years, the rhetoric of pronatalism in Turkey has come to dominate and raises questions about the availability of reproductive health care services, in particular contraception, from state run facilities. This study aimed to determine the availability of dedicated emergency contraception (EC) from government run Family Health Centers (FHCs) in Turkey. In 2019, a team of trained researchers called a random sample of 583 FHCs located in the largest cities in twelve regions across Turkey asking for dedicated EC. Dedicated EC is largely unavailable from government supported FHCs. Only 6.1% stated that they provided EC while 53.8% stated that it was not available and that they could provide no alternative. A further 28.3% declared that they could provide an alternative to dedicated EC that almost always consisted of oral contraceptives. We found statistically significant variations in response rate and availability among cities as well as the rate of referral to pharmacies. There is little access to EC from government sponsored health clinics designated to provide family planning services, which hinders access to an essential reproductive health care service that should be available to women everywhere.
Citation - WoS: 68
Citation - Scopus: 81
Banking Sector Reactions To Covid-19: the Role of Bank-Specific Factors and Government Policy Responses
(Elsevier, 2021) Demir, Ender; Danisman, Gamze Ozturk
This paper examines the impact of bank-specific factors and variations in the context of stringency of government policy responses on bank stock returns because of the COVID-19 pandemic. A sample of 1,927 publicly listed banks from 110 countries is used for the period of the first major wave of COVID-19, that is, January to May 2020. Our findings indicate that stock returns of banks with higher capitalization and deposits, more diversification, lower non-performing loans, and larger size are more resilient to the pandemic. While banks' environment and governance scores do not have a significant impact, higher social and corporate social responsibility strategy scores intensify the negative stock price reaction to COVID-19. We further observe that the pandemic induced reduction in bank stock prices is mitigated as the strictness of government policy responses increases, mainly through economic responses such as income support, debt and contract relief, and fiscal measures from governments.
Citation - WoS: 57
Citation - Scopus: 65
Beams: Backbone Extraction and Merge Strategy for the Global Many-To Alignment of Multiple Ppi Networks
(Oxford University Press, 2014) Alkan, Ferhat; Erten, Cesim
Motivation: Global many-to-many alignment of biological networks has been a central problem in comparative biological network studies. Given a set of biological interaction networks the informal goal is to group together related nodes. For the case of protein-protein interaction networks such groups are expected to form clusters of functionally orthologous proteins. Construction of such clusters for networks from different species may prove useful in determining evolutionary relationships in predicting the functions of proteins with unknown functions and in verifying those with estimated functions. Results: A central informal objective in constructing clusters of orthologous proteins is to guarantee that each cluster is composed of members with high homological similarity usually determined via sequence similarities and that the interactions of the proteins involved in the same cluster are conserved across the input networks. We provide a formal definition of the global many-to-many alignment of multiple protein-protein interaction networks that captures this informal objective. We show the computational intractability of the suggested definition. We provide a heuristic method based on backbone extraction and merge strategy (BEAMS) for the problem. We finally show through experiments based on biological significance tests that the proposed BEAMS algorithm performs better than the state-of-the-art approaches. Furthermore the computational burden of the BEAMS algorithm in terms of execution speed and memory requirements is more reasonable than the competing algorithms.
Citation - WoS: 2
Citation - Scopus: 2
Behavioral but Not Psychological Control Predicts Self-Regulation, Adjustment Problems and Academic Self-Efficacy Among Early Adolescents
(Routledge Journals, Taylor & Francis Ltd, 2025) Harma, Mehmet; Aktas, Busra; Sumer, Nebi
Prior work has documented that parental psychological and behavioral control have varying impacts on self-regulation skills and social-academic outcomes in early adolescence, with effects differing across cultures. The present study explores the role of psychological and behavioral control in predicting adjustment difficulties and academic self-confidence through self-regulatory skills among early adolescents in Turkiye using data from mothers and their children (N = 295, Ngirls=145, Mage=12.14 years). The results yielded that parental behavioral control, but not psychological control, predicts self-regulation of adolescents, which, in turn, predicts adjustment and academic self-efficacy. Our results underscore the pivotal role of parental knowledge and monitoring, mainly through behavioral control strategies, in fostering psychological adjustment and academic self-efficacy in the Turkish cultural context. The discussion delves into the potential culture-specific effects of psychological control and the universal influence of behavioral control during early adolescence.
Citation - Scopus: 9
Beyond Sightseeing: How Can Tourism Affect Public/Global Health in Modern Society?
(University of Edinburgh, 2022) Wen,J.; Kozak,M.; Jiang,Y.
[No abstract available]
Citation - WoS: 9
Citation - Scopus: 9
Beyond Sightseeing: How Can Tourism Affect Public/Global Health in Modern Society?
(Int Soc Global Health, 2022) Wen, Jun; Kozak, Metin; Jiang, Yangyang
[Abstract Not Available]
Citation - WoS: 2
Citation - Scopus: 2
Biased Perceptions Against Female Scientists Affect Intentions To Get Vaccinated for Covid-19
(Sage Publications Ltd, 2022) Dogan, Isminaz; Baruh, Lemi; Cemalcilar, Zeynep; Kuru, Ozan; Yildirim, Kerem; Carkoglu, Ali
Based on role congruity theory, we investigated how gender bias may influence public attitudes toward the vaccine in Turkey. Using a between-subjects design, we tested whether an emphasis on the female versus the male scientist as the vaccine's inventor in a news story influenced attitudes about the BioNTech vaccine and vaccination intentions. Partly confirming role congruity theory, three-way interaction results from 665 participants demonstrated that among male participants with a stronger belief in traditional gender roles (compared to males with lower belief), the presence of the female inventor, either by herself or together with the male inventor, decreased the perceived efficacy and safety of the vaccine and reduced intentions to be vaccinated by the BioNTech vaccine. We did not observe such differences for women. These findings highlight how gender bias may influence individuals' information processing and decision making in a way that may have negative consequences for public health.
Citation - WoS: 2
Citation - Scopus: 2
Biocontrol Potential of Vibrio Maritimus Chitinase: Heterologous Expression and Insecticidal Activity Against Acanthoscelides Obtectus
(Elsevier, 2025) Dikbas, Neslihan; Tulek, Ahmet; Ucar, Sevda; Alim, Seyma; Servili, Burak; Pacal, Nurettin; Ercisli, Sezai
In this study, the chitinase gene from the marine bacterium Vibrio maritimus was heterologously expressed in Escherichia coli, purified via affinity chromatography and tested for its insecticidal activity against the storage pest Acanthoscelides obtectus. The recombinant VmChiA protein exhibited a molecular mass of similar to 60 kDa, with optimum activity observed at pH 6.0 and 40 degrees C. Enzyme kinetic analysis revealed a K-m value of 0.042 mM, V-max of 17.48 mu mol min(-1), k(cat) of 1.75 min(-1) and catalytic efficiency of 41.61 mM(-1) min(-1), respectively. Furthermore, a dose of 40 U mL(-1) of recombinant VmChiA showed similar efficacy to malathion insecticide against A. obtectus, with 100 % mortality in both treatments. LC50 and LC90 values of VmChiA were 13.95 U mL(-1) and 27.66 U mL(-1), respectively. Furthermore, the three-dimensional structure of the catalytic site of VmChiA was modeled. Molecular dynamics simulation technique was used to explore and analyze the dynamics and interactions. A salt bridge (GLU274-ARG296) in the alpha + beta domain was observed as a critical feature facilitating substrate (GlcNAc)(2) binding and enzymatic activity. These findings demonstrate that recombinant VmChiA possesses potent insecticidal properties, highlighting its potential as a bio-based, eco-friendly alternative for managing significant agricultural pests.

Browse

Browsing PubMed İndeksli Yayınlar Koleksiyonu by WoS Q "Q1"