Browsing by Publisher "Cell Press"
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Publisher and Date:(Cell Press, 2014)
Publisher and Date:(Cell Press, 2015)The tunnel region at triosephosphate isomerase (TIM)'s dimer interface distant from its catalytic site is a target site for certain benzothiazole derivatives that inhibit TIM's catalytic activity in Trypanosoma cruzi the parasite that causes Chagas disease. We performed multiple 100-ns molecular-dynamics (MD) simulations and elastic network modeling (ENM) on both apo and complex structures to shed light on the still unclear inhibitory mechanism of one such inhibitor named bt10. Within the time ...
Prediction of the monomer-monomer ınterface region of the beta 2Ar homo-dimer receptor via docking experiments Authors:
Publisher and Date:(Cell Press, 2012)